Publication Name	World Journal of Gastroenterology
Manuscript ID	7356
Country	China

Received	2013-11-15 14:34
Peer-Review Started	2013-11-16 13:39
First Decision by Editorial Office Director
Return for Revision	2013-12-17 12:17
Revised	2014-01-13 22:36
Publication Fee Transferred
Second Decision by Editor	2014-02-20 15:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-02-20 15:51
Articles in Press
Edit the Manuscript by Language Editor	2014-03-23 11:29
Typeset the Manuscript	2014-04-22 08:56
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Resveratrol inhibits collagen Ⅰ synthesis by suppressing IGF-1R activation in intestinal fibroblasts
Manuscript Source	Invited Manuscript
All Author List	Ping Li, Mei-Lan Liang, Ying Zhu, Yao-Yao Gong, Yun Wang, Ding Heng and Lin Lin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81270462 International Cooperation Project of Jiangsu Province Department of Health SBZ201100103
Corresponding Author	Lin Lin, MD, PhD, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing 210029, Jiangsu Province, China. lin9100@aliyun.com
Key Words	Intestinal fibrosis; Insulin-like growth factor-1; Resveratrol; Silent information regulator 1; Fibroblasts
Core Tip	This study showed that the expression of silent information regulator 1 (SIRT1) was decreased in 2,4,6-trinitrobenzenesulfonic acid-induced colitis tissues, and resveratrol down-regulated insulin growth factor (IGF)-1-induced collagen Ⅰ synthesis by inhibiting IGF-1 receptor (IGF-1R) phosphorylation and its downstream extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in intestinal fibroblasts. Resveratrol alone suppressed collagen Ⅰ synthesis through up-regulating activity of SIRT1. Our data highlight a previously unknown function of resveratrol on IGF-1R activation and provide novel insight of resveratrol as a therapeutic agent for intestinal fibrosis.
Publish Date	2014-04-29 09:53
Citation	Li P, Liang ML, Zhu Y, Gong YY, Wang Y, Heng D, Lin L. Resveratrol inhibits collagen Ⅰ synthesis by suppressing IGF-1R activation in intestinal fibroblasts. World J Gastroenterol 2014; 20(16): 4648-4661
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4648.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4648

Full Article (PDF)	WJG-20-4648.pdf
Full Article (Word)	WJG-20-4648.doc
Manuscript File	7356-Review.doc
Answering Reviewers	7356-Answering reviewers.pdf
Copyright License Agreement	7356-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7356-Language certificate.pdf
Peer-review Report	7356-Peer reviews.pdf
Scientific Editor Work List	7356-Scientific editor work list.doc