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8/28/2014 5:50:00 PM | Browse: 477 | Download: 509
Publication Name World Journal of Gastroenterology
Manuscript ID 7356
Country/Territory China
2013-11-15 14:34
Peer-Review Started
2013-11-16 13:39
To Make the First Decision
2013-12-16 17:19
Return for Revision
2013-12-17 12:17
2014-01-13 22:36
Second Decision
2014-02-20 15:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-02-20 15:51
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-03-23 11:29
Typeset the Manuscript
2014-04-22 08:56
Publish the Manuscript Online
2014-04-29 09:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Resveratrol inhibits collagen Ⅰ synthesis by suppressing IGF-1R activation in intestinal fibroblasts
Manuscript Source Invited Manuscript
All Author List Ping Li, Mei-Lan Liang, Ying Zhu, Yao-Yao Gong, Yun Wang, Ding Heng and Lin Lin
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81270462
International Cooperation Project of Jiangsu Province Department of Health SBZ201100103
Corresponding Author Lin Lin, MD, PhD, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing 210029, Jiangsu Province, China. lin9100@aliyun.com
Key Words Intestinal fibrosis; Insulin-like growth factor-1; Resveratrol; Silent information regulator 1; Fibroblasts
Core Tip This study showed that the expression of silent information regulator 1 (SIRT1) was decreased in 2,4,6-trinitrobenzenesulfonic acid-induced colitis tissues, and resveratrol down-regulated insulin growth factor (IGF)-1-induced collagen Ⅰ synthesis by inhibiting IGF-1 receptor (IGF-1R) phosphorylation and its downstream extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in intestinal fibroblasts. Resveratrol alone suppressed collagen Ⅰ synthesis through up-regulating activity of SIRT1. Our data highlight a previously unknown function of resveratrol on IGF-1R activation and provide novel insight of resveratrol as a therapeutic agent for intestinal fibrosis.
Publish Date 2014-04-29 09:53
Citation Li P, Liang ML, Zhu Y, Gong YY, Wang Y, Heng D, Lin L. Resveratrol inhibits collagen Ⅰ synthesis by suppressing IGF-1R activation in intestinal fibroblasts. World J Gastroenterol 2014; 20(16): 4648-4661
URL http://www.wjgnet.com/1007-9327/full/v20/i16/4648.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i16.4648
Full Article (PDF) WJG-20-4648.pdf
Full Article (Word) WJG-20-4648.doc
Manuscript File 7356-Review.doc
Answering Reviewers 7356-Answering reviewers.pdf
Copyright License Agreement 7356-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 7356-Language certificate.pdf
Peer-review Report 7356-Peer reviews.pdf
Scientific Editor Work List 7356-Scientific editor work list.doc