Publication Name	World Journal of Biological Chemistry
Manuscript ID	7365
Country	China

Received	2013-11-15 15:03
Peer-Review Started	2013-11-16 15:32
To Make the First Decision	2013-12-25 18:05
Return for Revision	2013-12-31 15:20
Revised	2014-01-15 22:11
Second Decision	2014-03-18 15:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-18 15:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-19 12:11
Publish the Manuscript Online	2014-06-11 10:30

ISSN	1949-8454 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	FBW7-mediated ubiquitination and degradation of KLF5
Manuscript Source	Invited Manuscript
All Author List	Yi Luan and Ping Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Basic Research Program of China, 973 program 2010CB529704 National Basic Research Program of China, 973 program 2012CB910404 National Natural Science Foundation of China 30800587 National Natural Science Foundation of China 30971521 National Natural Science Foundation of China 31171338 Science and Technology Commission of Shanghai Municipality 11DZ2260300 a scholar of the Shanghai Rising-Star Program from Science and Technology Commission of Shanghai Municipality 09QA1401900 (to Wang P)
Corresponding Author	PhD, Professor, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. pwang@bio.ecnu.edu.c
Key Words	Krüppel-like factor 5; FBW7; Ubiquitin proteasome system; Degradation; Krüppel-like factor family
Core Tip	The protein levels of Krüppel-like factor (KLF)5 are tightly controlled in cell. Ubiquitination and destruction of KLF5 via FBW7, a famous tumor suppressor, has proved to have important roles in multiple cellular progresses by different studies. Here, we summarize these studies and show the physiological and pathological significance of FBW7-mediated degradation of KLF5.
Publish Date	2014-06-11 10:30
Citation	Luan Y, Wang P. FBW7-mediated ubiquitination and degradation of KLF5. World J Biol Chem 2014; 5(2): 216-223
URL	http://www.wjgnet.com/1949-8454/full/v5/i2/216.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i2.216

Full Article (PDF)	wjbc-5-216.pdf
Full Article (Word)	wjbc-5-216.doc
Manuscript File	7365-Review.doc
Answering Reviewers	7365-Answering reviewers.pdf
Copyright License Agreement	7365-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7365-Language certificate.pdf
Peer-review Report	7365-Peer reviews.pdf
Scientific Editor Work List	7365-Scientific editor work list.doc