Publication Name	World Journal of Gastroenterology
Manuscript ID	7388
Country	China

Received	2013-11-16 11:18
Peer-Review Started	2013-11-17 08:17
To Make the First Decision	2014-01-09 15:35
Return for Revision	2014-01-20 09:15
Revised
Second Decision	2014-03-06 17:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-06 18:17
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-11 08:41
Publish the Manuscript Online	2014-03-27 12:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Cortactin expression confers a more malignant phenotype to gastric cancer SGC-7901 cells
Manuscript Source	Invited Manuscript
All Author List	Jun Wei, Zhong-Xin Zhao, Yang Li, Zhu-Qing Zhou and Tian-Geng You
Funding Agency and Grant Number	Funding Agency Grant Number Project of Shanghai Science and Technology Commission of China 10411968400
Corresponding Author	Tian-Geng You, PhD, Department of Gastroenterological Surgery, Shanghai East Hospital, Tongji University School of Medicine, Jimo Rd 150, Shanghai 200120, China. tiangengyou2003@163.com
Key Words	Gastric cancer; Cortactin; Epidermal growth factor receptor; Invasion; Metastasis; Proliferation
Core Tip	Cortactin is an actin-related protein 2/3 complex-activating and filamentous (F)-actin-binding protein that is implicated in tumor cell motility and metastasis. Clinical studies have shown that cortactin overexpression is often associated with the clinicopathological parameters and poor prognosis in a variety of cancers, including gastric cancer. In this study, the effects of cortactin on gastric cancer progression were investigated. The results showed that cortactin expression promoted SGC-7901 cell migration, invasion and proliferation both in vitro and in vivo. The epidermal growth factor receptor signaling pathway is mechanistically involved. Cortactin may serve as a novel therapeutic target of gastric cancer.
Publish Date	2014-03-27 12:04
Citation	Wei J, Zhao ZX, Li Y, Zhou ZQ, You TG. Cortactin expression confers a more malignant phenotype to gastric cancer SGC-7901 cells. World J Gastroenterol 2014; 20(12): 3287-3300
URL	http://www.wjgnet.com/1007-9327/full/v20/i12/3287.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i12.3287

Full Article (PDF)	WJG-20-3287.pdf
Full Article (Word)	WJG-20-3287.doc
Manuscript File	7388-Review.docx
Answering Reviewers	7388-Answering reviewers.pdf
Copyright License Agreement	7388-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7388-Language certificate.pdf
Peer-review Report	7388-Peer reviews.pdf
Scientific Editor Work List	7388-Scientific editor work list.doc