Publication Name	World Journal of Gastroenterology
Manuscript ID	7389
Country	Japan

Received	2013-11-16 11:22
Peer-Review Started	2013-11-17 08:09
First Decision by Editorial Office Director
Return for Revision	2013-12-26 17:11
Revised
Publication Fee Transferred
Second Decision by Editor	2014-04-23 09:12
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-23 10:12
Articles in Press	2014-05-23 11:22
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-12 11:04
Publish the Manuscript Online	2014-06-27 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Impact of hepatitis C virus heterogeneity on interferon sensitivity: An overview
Manuscript Source	Invited Manuscript
All Author List	Ahmed El-Shamy and Hak Hotta
Funding Agency and Grant Number	Funding Agency Grant Number Health and Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare, Japan Japan International Cooperation Agency, and the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) program from the Ministry of Education, Culture, Sports, Science and Technology, Japan SATREPS Grant from Japan Science and Technology Agency
Corresponding Author	Hak Hotta, MD, PhD, Division of Microbiology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. hotta@kobe-u.ac.jp
Key Words	Hepatitis C virus; Interferon; Genotype; Core protein; Nonstructural proteins 5A; Interferon sensitivity-determining region; Interferon/ribavirin resistance-determining region
Core Tip	This review aims to cover recent updates on the impact of major hepatitis C virus (HCV) genetic factors, including HCV genotype, mutations in amino acids 70 and 91 of the core protein and sequence heterogeneity in interferon (IFN) sensitivity-determining region and IFN/ribavirin resistance-determining region of Nonstructural proteins 5A, on virological responses to IFN-based therapy.
Publish Date	2014-06-27 10:37
Citation	El-Shamy A, Hotta H. Impact of hepatitis C virus heterogeneity on interferon sensitivity: An overview. World J Gastroenterol 2014; 20(24): 7555-7569
URL	http://www.wjgnet.com/1007-9327/full/v20/i24/7555.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i24.7555

Full Article (PDF)	WJG-20-7555.pdf
Full Article (Word)	WJG-20-7555.doc
Manuscript File	7389-Review.doc
Answering Reviewers	7389-Answering reviewers.pdf
Copyright License Agreement	7389-Copyright assignment.pdf
Peer-review Report	7389-Peer reviews.pdf
Scientific Editor Work List	7389-Scientific editor work list.doc