Publication Name	World Journal of Stem Cells
Manuscript ID	7395
Country	Japan

Received	2013-11-16 11:41
Peer-Review Started	2013-11-16 16:23
To Make the First Decision	2013-12-10 14:35
Return for Revision	2013-12-17 16:31
Revised	2014-01-21 18:47
Second Decision	2014-05-08 17:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-08 17:58
Articles in Press	2014-05-23 13:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-18 11:31
Publish the Manuscript Online	2014-07-19 21:17

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	Mesenchymal stem cells for treatment of aortic aneurysms
Manuscript Source	Invited Manuscript
All Author List	Aika Yamawaki-Ogata, Ryotaro Hashizume, Xian-Ming Fu, Akihiko Usui and Yuji Narita
Funding Agency and Grant Number
Corresponding Author	Yuji Narita, MD, PhD, Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-Ku, Nagoya 466-8550, Japan. ynarita@med.nagoya-u.ac.jp
Key Words	Aortic aneurysm; Mesenchymal stem cells; Cell therapy; Elastin; Chronic inflammation; Extracellular matrices; Macrophages; Matrix metalloproteinases
Core Tip	Aortic aneurysm (AA) is caused by an imbalance between synthesis and degradation of extracellular matrices (ECMs) such as collagen and elastin in the aortic wall. The chronic inflammation enhances the degradation of ECMs directly and indirectly. We hypothesized that administration of mesenchymal stem cells (MSCs) might be able to treat AA given the anti-inflammatory and immune-suppressive potential of MSC. In this article, we review papers that attempt to treat AA using MSCs with our recent results, as well as review the molecular pathogenesis of AA and characteristics of MSC.
Publish Date	2014-07-19 21:17
Citation	Yamawaki-Ogata A, Hashizume R, Fu XM, Usui A, Narita Y. Mesenchymal stem cells for treatment of aortic aneurysms. World J Stem Cells 2014; 6(3): 278-287
URL	http://www.wjgnet.com/1948-0210/full/v6/i3/278.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i3.278

Full Article (PDF)	WJSC-6-278.pdf
Full Article (Word)	WJSC-6-278.doc
Manuscript File	7395-Review.docx
Answering Reviewers	7935-Answering reviewers.pdf
Copyright License Agreement	7935-Copyright assignment.pdf
Peer-review Report	7395-Peer review.pdf
Scientific Editor Work List	7935-Scientific editor work list.pdf