Publication Name	World Journal of Gastroenterology
Manuscript ID	73996
Country	Hungary

Received	2021-12-13 07:31
Peer-Review Started	2021-12-13 07:33
To Make the First Decision
Return for Revision	2022-01-23 06:34
Revised	2022-02-01 10:34
Second Decision	2022-04-20 02:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-04-25 19:54
Articles in Press	2022-04-25 19:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-04-13 04:10
Typeset the Manuscript	2022-05-20 08:19
Publish the Manuscript Online	2022-06-02 12:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Serological biomarkers for management of primary sclerosing cholangitis
Manuscript Source	Invited Manuscript
All Author List	David Tornai, Peter Laszlo Ven, Peter Laszlo Lakatos and Maria Papp
ORCID	Author(s) ORCID Number David Tornai http://orcid.org/0000-0002-1335-5498 Peter Laszlo Ven http://orcid.org/0000-0001-8990-7757 Peter Laszlo Lakatos http://orcid.org/0000-0002-3948-6488 Maria Papp http://orcid.org/0000-0003-3662-4010
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund 138041 EFOP projects co-financed by the European Union and the European Social Fund EFOP-3.6.1-16-2016-00022
Corresponding Author	Maria Papp, DSc, FEBG, MD, PhD, Full Professor, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei krt, Debrecen H-4032, Hajdu-Bihar, Hungary. papp.maria@med.unideb.hu
Key Words	Primary sclerosing cholangitis; Hepatobiliary; Serological biomarker; Immunoglobulin; Inflammatory; Tissue remodeling
Core Tip	Recent advances in biomarker research may help clinicians identify relevant subgroups of primary sclerosing cholangitis (PSC) and assist everyday clinical work-up. However, a diagnostic biomarker is still an unmet need. On the other hand, several biomarkers have been reported to predict outcome in PSC; however, most of them have not been validated by subsequent studies. The IgA type anti-glycoprotein 2 antibody is the first one to be supported by a satisfactory number of clinical studies and could be incorporated into clinical practice. These discoveries also reveal different aspects of PSC providing with potential therapeutic targets.
Publish Date	2022-06-02 12:11
Citation	Tornai D, Ven PL, Lakatos PL, Papp M. Serological biomarkers for management of primary sclerosing cholangitis. World J Gastroenterol 2022; 28(21): 2291-2301
URL	https://www.wjgnet.com/1007-9327/full/v28/i21/2291.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i21.2291

Full Article (PDF)	WJG-28-2291.pdf
Full Article (Word)	WJG-28-2291.docx
Manuscript File	73996_Auto_Edited_LM.docx
Answering Reviewers	73996-Answering reviewers.pdf
Audio Core Tip	73996-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	73996-Conflict-of-interest statement.pdf
Copyright License Agreement	73996-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	73996-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	73996-Language certificate.pdf
Supplementary Material	73996-Supplementary material.pdf
Peer-review Report	73996-Peer-review(s).pdf
Scientific Misconduct Check	73996-Bing-Chen YL-2.png
Scientific Editor Work List	73996-Scientific editor work list.pdf
CrossCheck Report	73996-CrossCheck report.pdf