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Articles Published Processes
4/19/2022 3:18:56 AM | Browse: 381 | Download: 590
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Received |
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2021-12-10 23:20 |
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Peer-Review Started |
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2021-12-10 23:22 |
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To Make the First Decision |
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Return for Revision |
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2022-02-15 00:44 |
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Revised |
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2022-02-17 19:04 |
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Second Decision |
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2022-03-25 06:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-03-27 06:18 |
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Articles in Press |
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2022-03-27 06:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-04-11 09:35 |
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Publish the Manuscript Online |
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2022-04-19 03:18 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Celina M Pollard, Malka S Suster, Natalie Cora, Alexandra M Carbone and Anastasios Lymperopoulos |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Anastasios Lymperopoulos, BPharm, FAHA, FESC, MSc, PhD, Associate Professor, Director, Director, Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, 3200 S. University Dr., HPD (Terry) Bldg/Room 1338, Fort Lauderdale, FL 33328-2018, United States. al806@nova.edu |
| Key Words |
Aldosterone; Cardiac myocyte; Finerenone; G protein-coupled receptor kinase-5; Mineralocorticoid receptor antagonist; Signal transduction |
| Core Tip |
G protein-coupled receptor-kinase (GRK)-5 blocks the cardiac actions of aldosterone via phosphorylation of the mineralocorticoid receptor (MR). We show here that the non-steroidal MR antagonist (MRA) finerenone may provide better cardio-protection against aldosterone than classic, steroidal MRAs, like eplerenone, thanks to induction of GRK5’s phosphorylation and subsequent blockade of cardiac MR. GRK5 is necessary for the anti-apoptotic, anti-oxidative, and anti-fibrotic effects of both finerenone and eplerenone against aldosterone but also for the higher efficacy/potency of the former drug at producing all these effects in cardiomyocytes. Thus, GRK5 acts as a co-repressor of the cardiac MR and is essential for efficient MR antagonism in the myocardium. |
| Publish Date |
2022-04-19 03:18 |
| Citation |
Pollard CM, Suster MS, Cora N, Carbone AM, Lymperopoulos A. GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone. World J Cardiol 2022; 14(4): 220-230 |
| URL |
https://www.wjgnet.com/1949-8462/full/v14/i4/220.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v14.i4.220 |
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