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Articles Published Processes
6/22/2022 8:29:42 AM | Browse: 390 | Download: 966
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Received |
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2021-12-27 11:28 |
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Peer-Review Started |
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2021-12-27 11:29 |
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To Make the First Decision |
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Return for Revision |
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2022-02-15 00:08 |
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Revised |
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2022-02-24 20:14 |
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Second Decision |
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2022-04-19 02:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-04-26 18:30 |
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Articles in Press |
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2022-04-26 18:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-05-24 09:32 |
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Typeset the Manuscript |
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2022-06-14 06:20 |
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Publish the Manuscript Online |
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2022-06-22 08:29 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alejandro Español, Yamila Sanchez, Agustina Salem, Jaqueline Obregon and Maria Elena Sales |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Buenos Aires (UBA) UBACYT 2018-2022 |
20020170100227 |
| National Research Council (CONICET) PIP 2015-2017 |
2015-0239 |
| National Agency for Scientific and Technological Promotion (ANPCyT) PICT 2015-2017 |
2015-2396 |
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| Corresponding Author |
Alejandro Español, PhD, Research Scientist, Laboratory of Immunopharmacology and Tumor Biology, CEFYBO CONICET University of Buenos Aires, Paraguay 2155 16th Floor, Buenos Aires C1121ABG, Argentina. aespan_1999@yahoo.com |
| Key Words |
Breast cancer; Paclitaxel; Nicotinic acetylcholine receptors; Drug therapy; Signal transduction; Drug transporter |
| Core Tip |
Smokers with lung tumors are more likely to generate resistance to chemotherapy than non-smokers. However, little is known about the effect of nicotinic activation during the treatment of breast cancer, a cancer which arises close to the lung. In triple negative human breast cells, nicotine reduces the chemotherapeutic effect of paclitaxel through the participation of several kinases, as well as by modulating ATP “binding cassette” G2 drug transporter expression and inducing resistance to treatment. These results indicate that nicotinic acetylcholine receptors are a new possible target in antitumor therapy for this subtype of breast cancer. |
| Publish Date |
2022-06-22 08:29 |
| Citation |
Español A, Sanchez Y, Salem A, Obregon J, Sales ME. Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells. World J Clin Oncol 2022; 13(6): 505-519 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i6/505.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i6.505 |
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