Publication Name	World Journal of Gastroenterology
Manuscript ID	74190
Country	China

Received	2021-12-16 13:21
Peer-Review Started	2021-12-16 13:23
To Make the First Decision
Return for Revision	2022-04-16 21:11
Revised	2022-04-27 06:29
Second Decision	2022-07-04 03:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-07-06 03:15
Articles in Press	2022-07-06 03:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-30 11:13
Typeset the Manuscript	2022-07-13 09:07
Publish the Manuscript Online	2022-08-03 07:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Involvement of nitrergic neurons in colonic motility in a rat model of ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Rong Li, Yan Li, Yuan Jin, Mang Xu, Hong-Wei Fan, Qian Zhang, Guo-He Tan, Jing Chen and Yun-Qing Li
ORCID	Author(s) ORCID Number Yan-Rong Li http://orcid.org/0000-0001-7830-1055 Yan Li http://orcid.org/0000-0001-5089-8574 Yuan Jin http://orcid.org/0000-0001-7184-2844 Mang Xu http://orcid.org/0000-0003-1017-1455 Hong-Wei Fan http://orcid.org/0000-0002-9546-593X Qian Zhang http://orcid.org/0000-0001-7249-4191 Guo-He Tan http://orcid.org/0000-0002-1101-207X Jing Chen http://orcid.org/0000-0001-9971-1053 Yun-Qing Li http://orcid.org/0000-0002-3707-3348
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31971112 Natural Science Foundation of Liaoning Province 2021-MS-330 Innovation Capability Support Program of Shaanxi 2021TD-57
Corresponding Author	Yun-Qing Li, PhD, Professor, Department of Human Anatomy, Basic Medical College, Guangxi Medical University, 22 Shuang-Yong Road, Nanning 530000, Guangxi Zhuang Autonomous Region, China. deptanat@fmmu.edu.cn
Key Words	Nitrergic neurons; Nitric oxide; Nitric oxide synthase; Ulcerative colitis; Colonic motility; Colonic myenteric plexus
Core Tip	This study focused on the effects of nitrergic neurons in the myenteric plexus (MP) on colonic motor function in rats with ulcerative colitis (UC). The results suggest that an increased number of nitrergic neurons in the colonic MP of the UC rats leads to reduced colon contractile function. Therefore, the regulation of the activity of nitrergic neurons in the colonic MP through interference with the activities of nitric oxide synthase might be a novel potential and prospective way to reduce the diarrhea symptoms in UC patients.
Publish Date	2022-08-03 07:54
Citation	Li YR, Li Y, Jin Y, Xu M, Fan HW, Zhang Q, Tan GH, Chen J, Li YQ. Involvement of nitrergic neurons in colonic motility in a rat model of ulcerative colitis. World J Gastroenterol 2022; 28(29): 3854-3868
URL	https://www.wjgnet.com/1007-9327/full/v28/i29/3854.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i29.3854

Full Article (PDF)	WJG-28-3854.pdf
Full Article (Word)	WJG-28-3854.docx
The ARRIVE Guidelines	74190-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	74190_Auto_Edited-YJM_WangTQ-LS.docx
Answering Reviewers	74190-Answering reviewers.pdf
Audio Core Tip	74190-Audio core tip.m4a
Biostatistics Review Certificate	74190-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	74190-Conflict-of-interest statement.pdf
Copyright License Agreement	74190-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	74190-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	74190-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	74190-Language certificate.pdf
Peer-review Report	74190-Peer-review(s).pdf
Scientific Editor Work List	74190-Scientific editor work list.pdf
CrossCheck Report	74190-CrossCheck report.pdf