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Articles Published Processes
6/10/2022 2:05:28 AM | Browse: 573 | Download: 1783
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Received |
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2021-12-18 06:20 |
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Peer-Review Started |
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2021-12-18 06:22 |
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First Decision by Editorial Office Director |
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2022-04-17 19:18 |
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Return for Revision |
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2022-04-17 19:18 |
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Revised |
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2022-04-22 16:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-05-20 03:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-05-23 00:45 |
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Articles in Press |
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2022-05-23 00:45 |
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Edit the Manuscript by Language Editor |
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2022-05-19 12:04 |
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Typeset the Manuscript |
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2022-06-07 03:20 |
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Publish the Manuscript Online |
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2022-06-10 02:05 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Wang, Meng-Nan Guo, Ning Li, De-Quan Pang and Jing-Hua Wu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| High-End Talent Funding Project in Hebei Province |
A202003005 |
| Hebei Provincial Health Commission Office |
G2019074 |
| Natural Science Foundation of Hebei Province |
H2019209355 |
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| Corresponding Author |
Jing-Hua Wu, MD, PhD, Chief Technician, Professor, Department of Laboratory Medicine, Tangshan Maternal and Child Health Care Hospital, North China University of Science and Technology, No. 1 Hetai Road, Lunan District, Tangshan 063000, Hebei Province, China. tswujinghua@163.com |
| Key Words |
Glutamine; Mitochondrial damage; CD8+ T cells; T cell function; Hepatocellular carcinoma |
| Core Tip |
This study aimed to investigate whether and how glutamine metabolism affects the function of infiltrating CD8+ T cells in hepatocellular carcinoma. Experimental validation was performed by using liver cancer tissues and cell lines. We discovered that glutamine deprivation impaired the function of infiltrating CD8+ T cells in hepatocellular carcinoma through the mitochondrial damage and apoptotic pathways. |
| Publish Date |
2022-06-10 02:05 |
| Citation |
Wang W, Guo MN, Li N, Pang DQ, Wu JH. Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis. World J Gastrointest Oncol 2022; 14(6): 1124-1140 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i6/1124.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i6.1124 |
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