Publication Name	World Journal of Biological Chemistry
Manuscript ID	7445
Country	United States

Received	2013-11-19 14:17
Peer-Review Started	2013-11-19 19:57
To Make the First Decision	2013-12-25 18:15
Return for Revision	2013-12-27 20:52
Revised	2014-01-16 03:14
Second Decision	2014-03-04 09:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-04 10:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-19 12:08
Publish the Manuscript Online	2014-06-11 10:30

ISSN	1949-8454 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Ophthalmology
Manuscript Type	Review
Article Title	Review of application of mass spectrometry for analyses of anterior eye proteome
Manuscript Source	Invited Manuscript
All Author List	Sherif Elsobky, Ashley M Crane, Michael Margolis, Teresia A Carreon and Sanjoy K Bhattacharya
Funding Agency and Grant Number
Corresponding Author	Sanjoy K Bhattacharya, PhD, Bascom Palmer Eye Institute, University of Miami, 1638 NW 10th Avenue, Suite 707A, Miami, FL 33136, United States. Sbhattacharya@med.miami.edu
Key Words	Mass spectrometry; Proteomics; Ocular; Glaucoma
Core Tip	Mass spectrometric based proteomics has been an indispensable tool for molecular and cellular biology. The ability of mass spectrometry to identify and precisely quantify thousands of proteins from complex samples has contributed greatly to biology and medicine. Through this we have studied protein-protein interactions via affinity-based isolations on a small and proteome-wide scale, the mapping of numerous organelles, and the generation of quantitative protein profiles from diverse species. The anterior segment of the eye is one of the most complicated parts of the human body with over 5000 proteins identified. Proteomic analyses of different parts of the eye, in particular the anterior eye structures, involve high throughput methods that help identify proteins and their posttranslational modifications. In this article we review the current state of advancement in the identification of anterior chamber proteins. We will present our findings in the following order: cornea, aqueous humor, trabecular meshwork, ciliary body, iris and lens.
Publish Date	2014-06-11 10:30
Citation	Elsobky S, Crane AM, Margolis M, Carreon TA, Bhattacharya SK. Review of application of mass spectrometry for analyses of anterior eye proteome. World J Biol Chem 2014; 5(2): 106-114
URL	http://www.wjgnet.com/1949-8454/full/v5/i2/106.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i2.106

Full Article (PDF)	wjbc-5-106.pdf
Full Article (Word)	wjbc-5-106.doc
Manuscript File	7445-Review.docx
Answering Reviewers	7445-Answering Reviewers.pdf
Copyright License Agreement	7445-Copyright assignment.pdf
Peer-review Report	7445-Peer review(s).pdf
Scientific Editor Work List	7445-Scientific editor work list.doc