Publication Name	World Journal of Clinical Cases
Manuscript ID	74452
Country	China

Received	2021-12-24 02:41
Peer-Review Started	2021-12-24 02:43
To Make the First Decision
Return for Revision	2022-02-14 08:57
Revised	2022-02-21 05:22
Second Decision	2022-05-30 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-03 21:18
Articles in Press	2022-06-03 21:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-23 13:56
Typeset the Manuscript	2022-07-02 10:43
Publish the Manuscript Online	2022-07-11 08:36

ISSN	2307-8960 (online)
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Category	Immunology
Manuscript Type	Opinion Review
Article Title	Effects of glucocorticoids on leukocyte: Genomic and non-genomic mechanisms
Manuscript Source	Unsolicited Manuscript
All Author List	Wan-Yu Jia and Jian-Jiang Zhang
ORCID	Author(s) ORCID Number Wan-Yu Jia http://orcid.org/0000-0001-6543-0501 Jian-Jiang Zhang http://orcid.org/0000-0003-2953-1924
Funding Agency and Grant Number	Funding Agency Grant Number Provinces Co-construction Program of Medical Science and Technique Foundation of Henan Province SB201901042 Key Scientific Research Project of Colleges and Universities in Henan Province 21A320070
Corresponding Author	Jian-Jiang Zhang, Doctor, MD, PhD, Chief Physician, Department of Pediatrics, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. zhangjianjiang1@hotmail.com
Key Words	Glucocorticoid; Leukocyte; Count; Functions; Glucocorticoid receptor
Core Tip	Glucocorticoids (GCs) increase peripheral blood neutrophil counts through genomic and nongenomic actions and reduce the numbers of lymphocytes, eosinophils, basophils, and monocytes. GCs also regulate cell activity and affect cells. The functions of adhesion, activation, secretion and differentiation inhibit the expression of proinflammatory factors and chemokines. The mechanisms of action of GCs include effects on intracellular transcription and protein expression, effects on mitochondria, physical and chemical interactions with biological membranes, and receptor-mediated interactions with signal proteins.
Publish Date	2022-07-11 08:36
Citation	Jia WY, Zhang JJ. Effects of glucocorticoids on leukocytes: Genomic and non-genomic mechanisms. World J Clin Cases 2022; 10(21): 7187-7194
URL	https://www.wjgnet.com/2307-8960/full/v10/i21/7187.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i21.7187

Full Article (PDF)	WJCC-10-7187.pdf
Full Article (Word)	WJCC-10-7187.docx
Manuscript File	74452_Auto_Edited-JRF-Webster J-LS.docx
Answering Reviewers	74452-Answering reviewers.pdf
Audio Core Tip	74452-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	74452-Conflict-of-interest statement.pdf
Copyright License Agreement	74452-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	74452-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	74452-Language certificate.pdf
Peer-review Report	74452-Peer-review(s).pdf
Scientific Misconduct Check	74452-Bing-Fan JR-2.png
Scientific Editor Work List	74452-Scientific editor work list.pdf