Publication Name	World Journal of Hepatology
Manuscript ID	74526
Country	India

Received	2021-12-27 08:20
Peer-Review Started	2021-12-27 08:21
To Make the First Decision
Return for Revision	2022-03-07 03:13
Revised	2022-04-21 04:03
Second Decision	2022-09-19 03:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-09-21 21:43
Articles in Press	2022-09-21 21:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-21 05:31
Typeset the Manuscript	2022-10-24 04:08
Publish the Manuscript Online	2022-10-27 03:05

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Natural history and management of liver dysfunction in lysosomal storage disorders
Manuscript Source	Invited Manuscript
All Author List	Moinak Sen Sarma and Parijat Ram Tripathi
ORCID	Author(s) ORCID Number Moinak Sen Sarma http://orcid.org/0000-0003-2015-4069 Parijat Ram Tripathi http://orcid.org/0000-0002-2690-3641
Funding Agency and Grant Number
Corresponding Author	Moinak Sen Sarma, MD, Associate Professor, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India. moinaksen@gmail.com
Key Words	Lysosomal; Gaucher; Niemann-Pick; Wolman; Cholesteryl ester; Children
Core Tip	Lysosomal storage disorders have a multisystem involvement. Gaucher disease, Niemann-Pick disease, and lysosomal acid lipase deficiency (Wolman disease and cholesteryl ester storage disorder) may have predominant liver dysfunction. Those with neonatal-onset, predominant severe extrahepatic and multi-systemic presentations often have challenging outcomes. Enzyme replacement therapy and liver transplantation are encouraged in select situations. Genetic tests and counseling are important aspects of management.
Publish Date	2022-10-27 03:05
Citation	Sen Sarma M, Tripathi PR. Natural history and management of liver dysfunction in lysosomal storage disorders. World J Hepatol 2022; 14(10): 1844-1861
URL	https://www.wjgnet.com/1948-5182/full/v14/i10/1844.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i10.1844

Full Article (PDF)	WJH-14-1844.pdf
Full Article (Word)	WJH-14-1844.docx
Manuscript File	74526_Auto_Edited-Ma JY.docx
Answering Reviewers	74526-Answering reviewers.pdf
Audio Core Tip	74526-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	74526-Conflict-of-interest statement.pdf
Copyright License Agreement	74526-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	74526-Language certificate.pdf
Peer-review Report	74526-Peer-review(s).pdf
Scientific Editor Work List	74526-Scientific editor work list.pdf
CrossCheck Report	74526-CrossCheck report.pdf