Publication Name	World Journal of Gastroenterology
Manuscript ID	7457
Country	Italy

Received	2013-11-20 13:54
Peer-Review Started	2013-11-20 15:21
To Make the First Decision	2014-01-09 16:45
Return for Revision	2014-01-12 17:46
Revised	2014-02-13 19:40
Second Decision	2014-06-26 17:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-26 17:27
Articles in Press	2014-06-26 17:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-08 18:11
Typeset the Manuscript	2014-10-08 17:28
Publish the Manuscript Online	2014-10-20 18:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Topic Highlights
Article Title	Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Paradies, Valeria Paradies, Francesca M Ruggiero and Giuseppe Petrosillo
Funding Agency and Grant Number
Corresponding Author	Giuseppe Paradies, Professor, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, via E Orabona 4, 70126 Bari, Italy. g.paradies@biologia.uniba.it
Key Words	Oxidative stress; Cardiolipin; Mitochondrial bioenergetics; Antioxidants; Nonalcoholic fatty liver disease
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is considered the most common form of chronic liver disease. Mitochondrial dysfunction and oxidative stress play a key role in the physiopathology of NAFLD. Mitochondrial respiratory chain is the main source of reactive oxygen species, which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid of the inner mitochondrial membrane, plays an important role in mitochondrial bioenergetics and in apoptosis. Cardiolipin abnormalities have been associated with mitochondrial dysfunction in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction in NAFLD.
Publish Date	2014-10-20 18:35
Citation	Paradies G, Paradies V, Ruggiero FM, Petrosillo G. Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease. World J Gastroenterol 2014; 20(39): 14205-14218
URL	http://www.wjgnet.com/1007-9327/full/v20/i39/14205.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i39.14205

Full Article (PDF)	WJG-20-14205.pdf
Full Article (Word)	WJG-20-14205.doc
Manuscript File	7457-Review.docx
Answering Reviewers	7457-Answering review.pdf
Copyright License Agreement	7457-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7457-Language certificate.pdf
Peer-review Report	7457-Peer review.pdf
Scientific Misconduct Check	7457-CorssCheck.jpg
Scientific Editor Work List	7457-Scientific editor work list.pdf