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7/13/2022 1:27:24 AM | Browse: 265 | Download: 850
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 74597
Country/Territory China
Received
2021-12-31 09:43
Peer-Review Started
2021-12-31 09:44
To Make the First Decision
Return for Revision
2022-03-10 08:14
Revised
2022-03-22 08:56
Second Decision
2022-05-23 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-28 07:06
Articles in Press
2022-05-28 07:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-07 05:04
Publish the Manuscript Online
2022-07-13 01:27
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pathology
Manuscript Type Basic Study
Article Title Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma
Manuscript Source Unsolicited Manuscript
All Author List Xi Wang, Cheng-Sheng Zhang, Xu-Yuan Dong, Yuan Hu, Bao-Jun Duan, Jun Bai, Yin-Ying Wu, Lin Fan, Xin-Hua Liao, Ye Kang, Peng Zhang, Meng-Yang Li, Jiao Xu, Zhi-Jun Mao, Hui-Tong Liu, Xiao-Long Zhang, Li-Fei Tian and En-Xiao Li
ORCID
Author(s) ORCID Number
Xi Wang http://orcid.org/0000-0001-9516-0397
Cheng-Sheng Zhang http://orcid.org/0000-0003-4792-7009
Xu-Yuan Dong http://orcid.org/0000-0003-2037-7852
Yuan Hu http://orcid.org/0000-0003-3267-1565
Bao-Jun Duan http://orcid.org/0000-0002-8375-7951
Jun Bai http://orcid.org/0000-0002-9063-3631
Yin-Ying Wu http://orcid.org/0000-0002-4132-2714
Lin Fan http://orcid.org/0000-0001-8260-1886
Xin-Hua Liao http://orcid.org/0000-0003-2171-9287
Ye Kang http://orcid.org/0000-0002-5735-8295
Peng Zhang http://orcid.org/0000-0002-5673-4404
Meng-Yang Li http://orcid.org/0000-0001-8270-2994
Jiao Xu http://orcid.org/0000-0002-6702-8855
Zhi-Jun Mao http://orcid.org/0000-0001-5689-5307
Hui-Tong Liu http://orcid.org/0000-0003-4585-7932
Xiao-Long Zhang http://orcid.org/0000-0003-3107-7046
Li-Fei Tian http://orcid.org/0000-0001-8374-3683
En-Xiao Li http://orcid.org/0000-0001-5225-0173
Funding Agency and Grant Number
Funding Agency Grant Number
Basic Research Project of Natural Science of Shaanxi Province 2020JQ-943
Basic Research Project of Natural Science of Shaanxi Province 2021JQ-916
Basic Research Project of Natural Science of Shaanxi Province 2021JQ-914
Research Project of Chinese Society of Clinical Oncology-Sai Sheng Fund Y-2020Sciclone/qn-0181
Science and Technology Support Program of Shaanxi Provincial People's Hospital 2021JY-26
Science and Technology Support Program of Shaanxi Provincial People's Hospital 2021JY-38
Science and Technology Support Program of Shaanxi Provincial People's Hospital 2021JY-50
Science and Technology Support Program of Shaanxi Provincial People's Hospital 2021BJ-13
Research Fund Project of Shaanxi Provincial People’s Hospital 2021YJY-18
China Postdoctoral Science Foundation 2021M702607
Corresponding Author En-Xiao Li, PhD, Professor, Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an 710061, Shaanxi, China. doclienxiao@sina.com
Key Words Pancreatic ductal adenocarcinoma; Claudin 18.2, Immunohistochemistry; Therapeutic target; Diagnosis; Prognosis
Core Tip Claudin 18.2 (CLDN18.2) shows a high rate of expression in pancreatic ductal adenocarcinoma (PDAC) but displays little expression in normal pancreatic tissue. CLDN18.2 expression significantly correlates with lymph node metastasis, distant metastasis, nerve invasion, stage, and survival of PDAC patients. Thus, CLDN18.2 may act as an ideal therapeutic target, and a considerable number of PDAC patients may be in eligible for a CLDN18.2-targeted therapeutic approach.
Publish Date 2022-07-13 01:27
Citation Wang X, Zhang CS, Dong XY, Hu Y, Duan BJ, Bai J, Wu YY, Fan L, Liao XH, Kang Y, Zhang P, Li MY, Xu J, Mao ZJ, Liu HT, Zhang XL, Tian LF, Li EX. Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol 2022; 14(7): 1252-1264
URL https://www.wjgnet.com/1948-5204/full/v14/i7/1252.htm
DOI https://dx.doi.org/10.4251/wjgo.v14.i7.1252
Full Article (PDF) WJGO-14-1252.pdf
Full Article (Word) WJGO-14-1252.docx
Manuscript File 74597_Auto_Edited-LS.docx
Answering Reviewers 74597-Answering reviewers.pdf
Audio Core Tip 74597-Audio core tip.mp3
Biostatistics Review Certificate 74597-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 74597-Conflict-of-interest statement.pdf
Copyright License Agreement 74597-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 74597-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 74597-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 74597-Language certificate.pdf
Supplementary Material 74597-Supplementary materials.pdf
Peer-review Report 74597-Peer-review(s).pdf
Scientific Editor Work List 74597-Scientific editor work list.pdf