Publication Name	World Journal of Gastroenterology
Manuscript ID	74629
Country	China

Received	2021-12-30 05:43
Peer-Review Started	2021-12-30 05:45
To Make the First Decision
Return for Revision	2022-04-16 07:11
Revised	2022-04-26 03:12
Second Decision	2022-06-21 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-06-26 06:40
Articles in Press	2022-06-26 06:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-07 09:00
Publish the Manuscript Online	2022-07-18 09:47

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Minireviews
Article Title	Application of intravoxel incoherent motion diffusion-weighted imaging in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Yi Zhou, Jing Zheng, Cui Yang, Juan Peng, Ning Liu, Lin Yang and Xiao-Ming Zhang
ORCID	Author(s) ORCID Number Yi Zhou http://orcid.org/0000-0002-1911-5380 Jing Zheng http://orcid.org/0000-0002-2031-0845 Cui Yang http://orcid.org/0000-0001-6751-9075 Juan Peng http://orcid.org/0000-0002-7961-3533 Ning Liu http://orcid.org/0000-0003-3587-5440 Lin Yang http://orcid.org/0000-0001-8746-9255 Xiao-Ming Zhang http://orcid.org/0000-0001-5327-8506
Funding Agency and Grant Number	Funding Agency Grant Number Project of department of Science and Technology of Sichuan Province 2016JY0105 Project of Medical Association of Sichuan Province S20070 Project of City-University Science and Technology Strategic Cooperation of Nanchong City (North Sichuan Medical College) 20SXQT0324
Corresponding Author	Lin Yang, MD, Professor, Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology, Medical Research Center, The Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, Nanchong 637000, Sichuan Province, China. linyangmd@163.com
Key Words	Hepatocellular carcinoma; Intravoxel incoherent motion; Differentiation; Pathological grading; Treatment response; Gene expression
Core Tip	Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) quantitatively measures information related to pure water molecule diffusion and microcirculation perfusion using a biexponential model, thus compensating for the shortcomings of traditional DWI. The number of studies assessing IVIM-DWI in patients with hepatocellular carcinoma (HCC) has gradually increased over the last few years. This review, which is based on the literature, identified an imaging biomarker for HCC differentiation, pathological grading, predicting and evaluating the treatment response, predicting postoperative recurrence and predicting gene expression prediction. The results of this analysis show that IVIM-DWI has important value in the treatment and diagnosis of HCC.
Publish Date	2022-07-18 09:47
Citation	Zhou Y, Zheng J, Yang C, Peng J, Liu N, Yang L, Zhang XM. Application of intravoxel incoherent motion diffusion-weighted imaging in hepatocellular carcinoma. World J Gastroenterol 2022; 28(27): 3334-3345
URL	https://www.wjgnet.com/1007-9327/full/v28/i27/3334.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i27.3334

Full Article (PDF)	WJG-28-3334.pdf
Full Article (Word)	WJG-28-3334.docx
Manuscript File	74629_Auto_Edited-LS.docx
Answering Reviewers	74629-Answering reviewers.pdf
Audio Core Tip	74629-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	74629-Conflict-of-interest statement.pdf
Copyright License Agreement	74629-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	74629-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	74629-Language certificate.pdf
Peer-review Report	74629-Peer-review(s).pdf
Scientific Editor Work List	74629-Scientific editor work list.pdf
CrossCheck Report	74629-CrossCheck report.pdf