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Articles Published Processes
5/24/2022 10:35:19 AM | Browse: 279 | Download: 664
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Received |
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2021-12-31 17:28 |
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Peer-Review Started |
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2021-12-31 17:29 |
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To Make the First Decision |
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Return for Revision |
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2022-02-21 19:12 |
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Revised |
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2022-03-01 03:56 |
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Second Decision |
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2022-05-06 02:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-05-07 00:50 |
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Articles in Press |
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2022-05-07 00:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-05-11 01:21 |
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Publish the Manuscript Online |
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2022-05-24 10:35 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chun-Ye Zhang and Ming Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| No external financial support. |
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| Corresponding Author |
Ming Yang, DVM, PhD, Postdoctoral Fellow, Department of Surgery, University of Missouri, 1030 Hitt Street, NexGen Precision Building, Room 2203, Columbia, MO 65211, United States. yangmin@health.missouri.edu |
| Key Words |
Hepatocellular carcinoma; Ubiquitin-conjugating enzyme 2; UBE2C; UBE2T; UBE2S; TP53 mutant; Biomarker; Diagnostic; Prognostics |
| Core Tip |
Liver cancer ranks the third cause of cancer-related death worldwide. The most common type of liver cancer is hepatocellular carcinoma (HCC). Lack of effective treatment options and early diagnostic biomarkers results in a short survival time of HCC patients. Ubiquitination plays an essential role in the biochemical processes in cells. In this study, using bioinformatic analysis of the online TCGA database we found that three ubiquitin-conjugating enzyme 2 (UBE2) genes were overexpressed in HCC samples compared to normal samples in a stage-dependent manner, including UBE2C, UBE2T, and UBE2S. Additionally, overexpression of those genes was negatively associated with prognostic outcomes and overall survival times. Patients with TP53 mutation showed a higher level of expression of three UBE2 genes, indicating an association between UBE2 expression with p53 function. This study shed light on the potential roles of UBE2C, UBE2T, and UBE2S on diagnostic and prognostic biomarkers for HCC, as well as the therapeutic strategy. |
| Publish Date |
2022-05-24 10:35 |
| Citation |
Zhang CY, Yang M. Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis. World J Meta-Anal 2022; 14(5): 956-971 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i5/956.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i5.956 |
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