Publication Name	World Journal of Gastroenterology
Manuscript ID	7470
Country	United States

Received	2013-11-20 15:23
Peer-Review Started	2013-11-20 19:40
To Make the First Decision	2014-03-28 18:32
Return for Revision	2014-03-29 12:05
Revised	2014-05-15 00:00
Second Decision	2014-06-13 11:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-13 12:47
Articles in Press	2014-06-13 13:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-01 09:44
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic
Manuscript Source	Invited Manuscript
All Author List	Telma Noguera, Robert Wotring, Chris R Melville, Kara Hargraves, Jochen Kumm and John M Morton
Funding Agency and Grant Number
Corresponding Author	John M Morton, MD, MPH, Chief of Bariatric and Minimally Invasive Surgery, Stanford School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305, United States. research@greenteaspoon.com
Key Words	Prebiotic; Gastroenteritis; Diarrhea; Rotavirus; Infant Mortality; Dehydration; Heartburn; Polyphenol; Aliva; Greenteaspoon
Core Tip	The global standard of care for treating acute gastroenteritis in children is 5-10 d of oral rehydration therapy, which saves lives and may reduce the duration of the illness by 20%. In this double-blind, placebo-controlled clinical study, 60% of subjects treated with a novel polyphenol-based prebiotic experienced their last unformed stool within 2 h vs 25% of the placebo treated subjects, and 89% within 24 h vs 38% of the placebo treated group. This represents a potentially extraordinary advance in the clinical management of acute gastroenteritis. If these results can be confirmed in additional studies with different populations, this treatment should become the new global standard of care.
Publish Date	2014-09-18 19:50
Citation	Noguera T, Wotring R, Melville CR, Hargraves K, Kumm J, Morton JM. Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic. World J Gastroenterol 2014; 20(34): 12301-12307
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/12301.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.12301

Full Article (PDF)	WJG-20-12301.pdf
Full Article (Word)	WJG-20-12301.doc
Manuscript File	7470-Review.docx
Answering Reviewers	7470-Answering reviewers.pdf
Copyright License Agreement	7470-Copyright assignment.pdf
Peer-review Report	7470-Peer review.pdf
Scientific Misconduct Check	7470-CorssCheck.jpg
Scientific Editor Work List	7470-Scientific editor work list.pdf