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Articles Published Processes
8/26/2022 7:50:06 AM | Browse: 610 | Download: 1867
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Received |
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2022-01-10 13:54 |
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Peer-Review Started |
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2022-01-10 13:57 |
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First Decision by Editorial Office Director |
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2022-04-16 07:00 |
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Return for Revision |
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2022-04-16 07:00 |
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Revised |
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2022-04-26 07:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-06-22 09:14 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-06-26 06:38 |
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Articles in Press |
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2022-06-26 06:38 |
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Edit the Manuscript by Language Editor |
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2022-06-06 04:06 |
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Typeset the Manuscript |
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2022-07-13 07:48 |
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Publish the Manuscript Online |
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2022-08-26 07:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-tumour activity and toxicological studies of combination treatment of Orthosiphon stamineus and gemcitabine on pancreatic xenograft model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ashwaq Hamid Salem Yehya, Ayappa V Subramaniam, Muhammad Asif, Gurjeet Kaur, Amin MS Abdul Majid and Chern Ein Oon |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NKEA Research Grant Scheme (NRGS) by the Ministry of Agriculture Malaysia |
304/CIPPM/650736/k123 |
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| Corresponding Author |
Chern Ein Oon, PhD, Associate Professor, Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Chancellory II, Penang 11800, Malaysia. chern.oon@usm.my |
| Key Words |
Pancreatic cancer; Orthosiphon stamineus; C5EOSEW5050ESA; Gemcitabine; Complementary medicine |
| Core Tip |
The combination of C5EOSEW5050ESA at 400 mg/kg and gemcitabine synergistically reduced tumour growth compared to either drug alone by reducing Ki-67 cell proliferation marker and tumour necrosis. In addition, no signs of toxicity or damage to vital organs in single C5EOSEW5050ESA or gemcitabine and chemo-herbal combinations treated animals compared to the untreated group, indicating the safety and efficacy of the combination treatment in a short term study. Findings from this study may provide the basis for product formulation and manufacturing of botanical drugs to be used as complementary medicine for the treatment of cancer. |
| Publish Date |
2022-08-26 07:50 |
| Citation |
Yehya AHS, Subramaniam AV, Asif M, Kaur G, Abdul Majid AMS, Oon CE. Anti-tumour activity and toxicological studies of combination treatment of Orthosiphon stamineus and gemcitabine on pancreatic xenograft model. World J Gastroenterol 2022; 28(32): 4620-4634 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i32/4620.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i32.4620 |
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