Publication Name	World Journal of Gastroenterology
Manuscript ID	74749
Country	Malaysia

Received	2022-01-10 13:54
Peer-Review Started	2022-01-10 13:57
To Make the First Decision
Return for Revision	2022-04-16 07:00
Revised	2022-04-26 07:34
Second Decision	2022-06-22 09:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-26 06:38
Articles in Press	2022-06-26 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-06 04:06
Typeset the Manuscript	2022-07-13 07:48
Publish the Manuscript Online	2022-08-26 07:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Anti-tumour activity and toxicological studies of combination treatment of Orthosiphon stamineus and gemcitabine on pancreatic xenograft model
Manuscript Source	Unsolicited Manuscript
All Author List	Ashwaq Hamid Salem Yehya, Ayappa V Subramaniam, Muhammad Asif, Gurjeet Kaur, Amin MS Abdul Majid and Chern Ein Oon
ORCID	Author(s) ORCID Number Ashwaq Hamid Salem Yehya http://orcid.org/0000-0001-7464-1618 Ayappa V Subramaniam http://orcid.org/0000-0002-3302-6704 Muhammad Asif http://orcid.org/0000-0001-8989-9945 Gurjeet Kaur http://orcid.org/0000-0002-6232-5703 Amin MS Abdul Majid http://orcid.org/0000-0001-7499-2258 Chern Ein Oon http://orcid.org/0000-0002-4685-6408
Funding Agency and Grant Number	Funding Agency Grant Number NKEA Research Grant Scheme (NRGS) by the Ministry of Agriculture Malaysia 304/CIPPM/650736/k123
Corresponding Author	Chern Ein Oon, PhD, Associate Professor, Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Chancellory II, Penang 11800, Malaysia. chern.oon@usm.my
Key Words	Pancreatic cancer; Orthosiphon stamineus; C5EOSEW5050ESA; Gemcitabine; Complementary medicine
Core Tip	The combination of C5EOSEW5050ESA at 400 mg/kg and gemcitabine synergistically reduced tumour growth compared to either drug alone by reducing Ki-67 cell proliferation marker and tumour necrosis. In addition, no signs of toxicity or damage to vital organs in single C5EOSEW5050ESA or gemcitabine and chemo-herbal combinations treated animals compared to the untreated group, indicating the safety and efficacy of the combination treatment in a short term study. Findings from this study may provide the basis for product formulation and manufacturing of botanical drugs to be used as complementary medicine for the treatment of cancer.
Publish Date	2022-08-26 07:50
Citation	Yehya AHS, Subramaniam AV, Asif M, Kaur G, Abdul Majid AMS, Oon CE. Anti-tumour activity and toxicological studies of combination treatment of Orthosiphon stamineus and gemcitabine on pancreatic xenograft model. World J Gastroenterol 2022; 28(32): 4620-4634
URL	https://www.wjgnet.com/1007-9327/full/v28/i32/4620.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i32.4620

Full Article (PDF)	WJG-28-4620.pdf
Full Article (Word)	WJG-28-4620.docx
The ARRIVE Guidelines	74749-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	74749_Auto_Edited-YJM-FilipodiaCL-LS.docx
Answering Reviewers	74749-Answering reviewers.pdf
Audio Core Tip	74749-Audio core tip.m4a
Biostatistics Review Certificate	74749-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	74749-Conflict-of-interest statement.pdf
Copyright License Agreement	74749-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	74749-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	74749-Institutional animal care and use committee statement.pdf
Peer-review Report	74749-Peer-review(s).pdf
Scientific Editor Work List	74749-Scientific editor work list.pdf