Publication Name	World Journal of Gastroenterology
Manuscript ID	7477
Country	United States

Received	2013-11-20 16:15
Peer-Review Started	2013-11-20 20:27
To Make the First Decision	2014-01-09 16:24
Return for Revision	2014-01-12 17:50
Revised	2014-03-02 12:04
Second Decision	2014-04-16 11:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-16 12:04
Articles in Press	2014-05-23 09:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-27 13:28
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biology
Manuscript Type	Topic Highlights
Article Title	STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Andrew V Nguyen, Yuan-Yuan Wu and Elaine Y Lin
Funding Agency and Grant Number
Corresponding Author	Elaine Y Lin, PhD, Assistant Professor, Department of Medicine, Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, United States. elaine.lin@einstein.yu.edu
Key Words	Sphingosine-1-phosphate; Signal transducer and activator of transcription 3; Interleukin-6; Inflammation; Colorectal cancer; Tumorigenesis; Tumor progression; Inflammatory bowel disease
Core Tip	Patients with inflammatory bowel diseases have a predisposition for the development of colorectal cancer (CRC). We summarize current literature on the interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3) inflammatory pathway and its association with CRC. Recent papers within the last couple of years have demonstrated the crosstalk between IL-6, STAT3 and sphingosine-1-phosphate pathways in inflammation associated tumorigenesis in intestine. This signaling cascade in tumor cells appears to be an essential pathway for CRC tumor progression. Current therapies exploiting sphingolipid signaling have provided an attractive strategy against inflammation-associated CRC.
Publish Date	2014-08-18 16:49
Citation	Nguyen AV, Wu YY, Lin EY. STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. World J Gastroenterol 2014; 20(30): 10279-10287
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10279.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10279

Full Article (PDF)	WJG-20-10279.pdf
Full Article (Word)	WJG-20-10279.doc
Manuscript File	7477-Review.doc
Answering Reviewers	7477-Answering reviewers.pdf
Copyright License Agreement	7477-Copyright assignment.pdf
Peer-review Report	7477-Peer Review.pdf
Scientific Editor Work List	7477-Scientific editor work list.doc