Publication Name	World Journal of Gastroenterology
Manuscript ID	7479
Country	South Korea

Received	2013-11-21 10:14
Peer-Review Started	2013-11-21 18:52
To Make the First Decision	2013-12-26 11:01
Return for Revision	2013-12-27 21:05
Revised	2014-01-06 14:57
Second Decision	2014-02-20 09:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 09:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-13 10:42
Publish the Manuscript Online	2014-06-06 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Topic Highlights
Article Title	Critical pathogenic steps to high risk Helicobacter pylori gastritis and gastric carcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Inchul Lee
Funding Agency and Grant Number
Corresponding Author	Inchul Lee, Professor, Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 43 Olympic Road 88, Songpa-Gu, Seoul 138-736, South Korea. iclee@amc.seoul.kr
Key Words	Helicobacter pylori; Atypical Malgun cell; Neutrophilic foveolitis; Stomach; Cancer; Gastritis; Pathology; Premalignant
Core Tip	Two critical pathogenic steps of high risk Helicobacter pylori (H. pylori) gastritis and gastric carcionogenesis are reviewed. Neutrophilic proliferative zone foveolitis is a critical pathogenic step in H. pylori gastritis inducing intensive epithelial damage. It is suggested to provide a new therapeutic goal replacing traditional bactericidal antibiotics approach. Atypical Malgun cell change is a novel premalignant condition in high risk gastropathy, which may progress and undergo malignant transformation directly. A new diagnosis system of gastritis is proposed based on the critical pathologic steps classifying low and high risk gastritis for separate treatment modality.
Publish Date	2014-06-06 16:55
Citation	Lee I. Critical pathogenic steps to high risk Helicobacter pylori gastritis and gastric carcinogenesis. World J Gastroenterol 2014; 20(21): 6412-6419
URL	http://www.wjgnet.com/1007-9327/full/v20/i21/6412.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i21.6412

Full Article (PDF)	WJG-20-6412.pdf
Full Article (Word)	WJG-20-6412.doc
Manuscript File	7479-Review.docx
Answering Reviewers	7479-Answering reviewers.pdf
Copyright License Agreement	7479-Copyright assignment.pdf
Peer-review Report	7479-Peer review(s).pdf
Scientific Editor Work List	7479-Scientific editor work list.doc