Publication Name	World Journal of Hepatology
Manuscript ID	7480
Country	Greece

Received	2013-11-21 10:29
Peer-Review Started	2013-11-21 18:57
To Make the First Decision	2013-12-25 18:13
Return for Revision	2013-12-27 20:43
Revised	2014-01-20 14:02
Second Decision	2014-03-04 09:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-04 10:24
Articles in Press	2014-05-27 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-18 20:05
Publish the Manuscript Online	2014-05-27 11:34

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Anesthesiology
Manuscript Type	Autobiography
Article Title	CYP2E1 immunoglobulin G4 subclass antibodies after desflurane anesthesia
Manuscript Source	Invited Manuscript
All Author List	Chrysanthi Batistaki, George Michalopoulos, Paraskevi Matsota, Tzortzis Nomikos, Konstantinos Kalimeris, Maria Riga, Maria Nakou and Georgia Kostopanagiotou
Funding Agency and Grant Number
Corresponding Author	Chrysanthi Batistaki, Assistant Professor of Anesthesiology, 2nd Department of Anesthesiology, School of Medicine, University of Athens, “Attikon Hospital”, 1 Rimini str, 12462 Athens, Greece. chrysabatistaki@yahoo.gr
Key Words	Drug-induced-liver injury; Desflurane; Anesthesia; Hepatotoxicity; CYP2E1 IgG4
Core Tip	Several case reports of hepatotoxicity following anesthesia with desflurane have been published in the literature, implicating cytochrome P450 2E1-IgG4 autoantibodies. This study investigates the possible changes in CYP2E1 IgG4 autoantibody levels and other biochemical markers of liver injury in 40 adult patients who received anesthesia with desflurane for elective surgery. Samples were obtained before and 96 h after exposure to desflurane, and no significant difference was observed in levels of CYP2E1 IgG4, a-glutamyl-S-transferase, aspartate aminotransferase, alanine aminotransferase, g-glutamyl-transpeptidase or alkaline phosphatase levels, regardless of patients’ previous exposure to volatile anesthetics.
Publish Date	2014-05-27 11:34
Citation	Batistaki C, Michalopoulos G, Matsota P, Nomikos T, Kalimeris K, Riga M, Nakou M, Kostopanagiotou G. CYP2E1 immunoglobulin G4 subclass antibodies after desflurane anesthesia. World J Hepatol 2014; 6(5): 340-346
URL	http://www.wjgnet.com/1948-5182/full/v6/i5/340.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i5.340

Full Article (PDF)	WJH-6-340.pdf
Full Article (Word)	WJH-6-340.doc
Manuscript File	7480-Review.doc
Answering Reviewers	7480-Answering reviewers.pdf
Copyright License Agreement	7480-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131120180820.pdf
Non-Native Speakers of English Editing Certificate	7480-Language certificate.pdf
Peer-review Report	7480-Peer review(s).pdf
Scientific Editor Work List	7480-Scientific editor work list.doc