Publication Name	World Journal of Gastroenterology
Manuscript ID	74848
Country	United States

Received	2022-01-10 23:00
Peer-Review Started	2022-01-10 23:02
To Make the First Decision
Return for Revision	2022-03-08 21:27
Revised	2022-03-15 01:17
Second Decision	2022-05-07 07:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-05-08 07:15
Articles in Press	2022-05-08 07:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-06-10 08:14
Publish the Manuscript Online	2022-06-24 13:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Rebuilding trust in proton pump inhibitor therapy
Manuscript Source	Invited Manuscript
All Author List	Alla Turshudzhyan, Sonia Samuel, Angela Tawfik and Micheal Tadros
ORCID	Author(s) ORCID Number Alla Turshudzhyan http://orcid.org/0000-0001-6867-7569 Sonia Samuel http://orcid.org/0000-0003-3359-0222 Angela Tawfik http://orcid.org/0000-0002-0001-8126 Micheal Tadros http://orcid.org/0000-0003-3118-3893
Funding Agency and Grant Number
Corresponding Author	Micheal Tadros, FACG, MD, Associate Professor, Department of Gastroenterology and Hepatology, Albany Medical College, 49 New Scotland Ave, Albany, NY 12208, United States. tadrosm1@amc.edu
Key Words	Proton pump inhibitor; Side-effects; Gastro-esophageal reflux disease; Therapy
Core Tip	Proton pump inhibitor (PPI) therapy is a cornerstone therapy for acid-related diseases. Its clinical success can be attributed to anti-secretory properties superior to any prior agents and seemingly low side-effects profile. As more patients were started and continued PPI therapy long-term, some studies began reporting side-effects associated with this therapy. Concerns over risks associated with PPI use grew over the last couple of years among both patients and providers. We hope to bring awareness to the current guidelines and the evidence behind the reported side-effects as better understanding of this evidence can improve medical practice. Both patients and providers should have all the evidence at hand when discussing initiation or continuation of PPI therapy.
Publish Date	2022-06-24 13:12
Citation	Turshudzhyan A, Samuel S, Tawfik A, Tadros M. Rebuilding trust in proton pump inhibitor therapy. World J Gastroenterol 2022; 28(24): 2667-2679
URL	https://www.wjgnet.com/1007-9327/full/v28/i24/2667.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i24.2667

Full Article (PDF)	WJG-28-2667.pdf
Full Article (Word)	WJG-28-2667.docx
Manuscript File	74848_Auto_Edited.docx
Answering Reviewers	74848-Answering reviewers.pdf
Audio Core Tip	74848-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	74848-Conflict-of-interest statement.pdf
Copyright License Agreement	74848-Copyright license agreement.pdf
Peer-review Report	74848-Peer-review(s).pdf
Scientific Misconduct Check	74848-Bing-Chen YL-2.png
Scientific Editor Work List	74848-Scientific editor work list.pdf
CrossCheck Report	74848-CrossCheck report.pdf