Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	7488
Country	United States

Received	2013-11-21 15:35
Peer-Review Started	2013-11-21 19:57
To Make the First Decision	2013-12-25 18:13
Return for Revision	2013-12-27 20:40
Revised	2014-01-14 04:06
Second Decision	2014-02-18 11:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-18 12:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-12 20:53
Publish the Manuscript Online	2014-03-20 18:58

ISSN	1948-5204 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Role of antioxidants and pro-oxidants in colon cancer
Manuscript Source	Invited Manuscript
All Author List	William L Stone, Koyamangalath Krishnan, Sharon E Campbell and Victoria E Palau
Funding Agency and Grant Number
Corresponding Author	William L Stone, PhD, Professor, Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Box 70578, Dogwood Lane, Johnson City, TN 37614, United States. stone@etsu.edu
Key Words	Colorectal cancer; Vitamin E; Tocopherols; Tocotrienols; Oxidative stress; Microbiome; Intestinal; Cyclooxygenase-2; Intestinal microfold cells; Alcohol; Cigarette smoke; Antioxidants; Genotoxicity
Core Tip	This review summarizes the roles that antioxidant and pro-oxidant factors play in the development of colorectal cancer (CRC). This review is timely since our understanding of the roles these factors play in CRC has made major advances and is now ripe for translational research efforts. A systems biology research approach appears to be optimal since environmental pro-oxidative stress factors (such as cigarette smoking, a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake) are likely to interact with the intestinal microbiome causing genotoxic damage to the epithelial cells of the large intestine and CRC.
Publish Date	2014-03-20 18:58
Citation	Stone WL, Krishnan K, Campbell SE, Palau VE. The role of antioxidants and pro-oxidants in colon cancer. World J Gastrointest Oncol 2014; 6(3): 55-66
URL	http://www.wjgnet.com/1948-5204/full/v6/i3/55.htm
DOI	http://dx.doi.org/10.4251/wjgo.v6.i3.55

Full Article (PDF)	wjgo-6-55.pdf
Full Article (Word)	wjgo-6-55.doc
Manuscript File	7488-Review.docx
Answering Reviewers	7488-Answering reviewers.pdf
Copyright License Agreement	7488-Copyright assignment.pdf
Peer-review Report	7488-Peer review(s).pdf
Scientific Editor Work List	7488-Scientific editor work list.doc