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Articles Published Processes
6/24/2022 1:12:05 PM | Browse: 557 | Download: 1158
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Received |
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2022-01-17 18:14 |
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Peer-Review Started |
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2022-01-17 18:15 |
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To Make the First Decision |
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Return for Revision |
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2022-03-08 05:55 |
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Revised |
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2022-03-21 18:24 |
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Second Decision |
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2022-05-16 03:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-05-17 02:08 |
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Articles in Press |
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2022-05-17 02:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-05-12 20:09 |
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Typeset the Manuscript |
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2022-06-14 08:31 |
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Publish the Manuscript Online |
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2022-06-24 13:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Patient-derived organoids for therapy personalization in inflammatory bowel diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Marianna Lucafò, Antonella Muzzo, Martina Marcuzzi, Lorenzo Giorio, Giuliana Decorti and Gabriele Stocco |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Giuliana Decorti, MD, Associate Professor, Advanced Translational Diagnostics Laboratory, Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Via dell’Istria 65/1, Trieste 34137, Italy. giuliana.decorti@burlo.trieste.it |
| Key Words |
Inflammatory bowel disease; Organoids; Intestinal epithelium; 3D cell cultures; Personalized medicine |
| Core Tip |
Intestinal organoids have helped to unveil knowledge about inflammatory bowel diseases pathogenesis, focusing on the genetic and epigenetic factors involved in the onset of these diseases, the altered intestinal epithelial cell (IEC) functions and the interplay between IECs and other surrounding cells, including immune cells and the intestinal bacteria. Intestinal organoids are currently being evaluated in pre-clinical studies as pharmacological tools to better understand the specific mechanisms of action of already used drugs on the IECs and to identify novel pharmacological targets and approaches. |
| Publish Date |
2022-06-24 13:12 |
| Citation |
Lucafò M, Muzzo A, Marcuzzi M, Giorio L, Decorti G, Stocco G. Patient-derived organoids for therapy personalization in inflammatory bowel diseases. World J Gastroenterol 2022; 28(24): 2636-2653 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i24/2636.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i24.2636 |
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