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Articles Published Processes
7/18/2022 9:47:46 AM | Browse: 475 | Download: 1539
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Received |
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2022-01-11 05:48 |
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Peer-Review Started |
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2022-01-11 05:50 |
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To Make the First Decision |
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Return for Revision |
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2022-03-08 21:19 |
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Revised |
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2022-03-15 05:49 |
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Second Decision |
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2022-06-22 09:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-26 06:37 |
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Articles in Press |
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2022-06-26 06:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-13 04:44 |
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Publish the Manuscript Online |
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2022-07-18 09:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keun-Yeong Jeong, Jae Jun Sim, Minhee Park and Hwan Mook Kim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Keun-Yeong Jeong, PhD, Executive Vice President, Research Assistant Professor, Research and Development, Metimedi Pharmaceuticals, 263 Central-ro, Incheon 22006, South Korea. alvirus@naver.com |
| Key Words |
Pancreatic cancer; Calcium; Reactive oxygen species; Poly adenosine diphosphate-ribose; Poly adenosine diphosphate-ribosylation; Poly adenosine diphosphate-ribose polymerase; Apoptosis-inducing factor; Nicotinamide adenine dinucleotide; Anticancer effect |
| Core Tip |
Accumulation of poly adenosine diphosphate-ribose (PAR) was induced by an increase in reactive oxygen species following sustained calcium supply, which in turn led to the death of pancreatic cancer cells by energy deprivation and apoptosis-inducing factor expression. Although calcium-mediated accumulation of PAR would be a potential strategy for the treatment of pancreatic cancer, the association with the mechanical role of calcium in enabling the inactivation of PAR-degrading enzymes needs to be elucidated. |
| Publish Date |
2022-07-18 09:47 |
| Citation |
Jeong KY, Sim JJ, Park M, Kim HM. Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells. World J Gastroenterol 2022; 28(27): 3422-3434 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i27/3422.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i27.3422 |
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