| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Observational Study |
| Article Title |
Usefulness of serum C-reactive protein and calprotectin for the early detection of colorectal anastomotic leakage: A prospective observational study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nuno J G Rama, Marlene C C Lages, Maria Pedro S Guarino, Óscar Lourenço, Patrícia C Motta Lima, Diana Parente, Cândida S G Silva, Ricardo Castro, Ana Bento, Anabela Rocha, Fernando Castro-Pocas and João Pimentel |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Ministry of Health – Incentive Program for the Integration of Care and Valuation of Patients’ Pathways in the National Health Service of Portugal |
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| Corresponding Author |
Nuno J G Rama, FEBS, MD, MHSc, Associate Professor, Research Assistant Professor, Surgeon, Colorectal Surgical Division, Leiria Hospital Centre, Rua das Olhalvas, Leiria 2410-021, Portugal. ramanuno@gmail.com |
| Key Words |
Anastomotic leakage; Colorectal; Surgery; Biomarkers; C-reactive protein; Calprotectin |
| Core Tip |
Colorectal anastomotic leakage (CAL) remains a serious postoperative complication. It is associated with high morbidity rates, affecting overall costs and patients’ quality of life. Clinical criteria, imaging studies, and biomarkers have been considered to increase diagnostic accuracy. Plasma C-reactive protein, calprotectin, procalcitonin, white blood cell count, and eosinophil cell count have been proposed as predictors of anastomotic leakage. The combination of C-reactive protein and calprotectin after a minimal clinical suspicion of CAL has shown good diagnostic accuracy, allowing clinicians to reduce the time to CAL detection. Regression models can facilitate building a decision model, as the score proposed for the early detection of CAL. |
| Publish Date |
2022-06-24 13:12 |
| Citation |
Rama NJG, Lages MCC, Guarino MPS, Lourenço Ó, Motta Lima PC, Parente D, Silva CSG, Castro R, Bento A, Rocha A, Castro-Pocas F, Pimentel J. Usefulness of serum C-reactive protein and calprotectin for the early detection of colorectal anastomotic leakage: A prospective observational study. World J Gastroenterol 2022; 28(24): 2758-2774 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i24/2758.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i24.2758 |
