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Articles Published Processes
8/3/2022 7:54:39 AM | Browse: 419 | Download: 921
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Received |
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2022-01-13 10:37 |
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Peer-Review Started |
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2022-01-13 10:38 |
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To Make the First Decision |
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Return for Revision |
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2022-05-29 07:59 |
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Revised |
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2022-06-07 15:14 |
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Second Decision |
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2022-06-29 03:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-06 14:22 |
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Articles in Press |
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2022-07-06 14:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-25 02:37 |
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Publish the Manuscript Online |
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2022-08-03 07:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Structural changes of proteins in liver cirrhosis and consequential changes in their function
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nikola Gligorijević, Simeon Minić and Olgica Nedić |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Science and Technological Development of the Republic of Serbia |
451-03-9/2021-14/200019 |
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| Corresponding Author |
Nikola Gligorijević, PhD, Research Associate, Department of Metabolism, University of Belgrade-Institute for the Application of Nuclear Energy, Banatska 31b, Belgrade 11080, Serbia. nikolag@inep.co.rs |
| Key Words |
Liver cirrhosis; Post-translational modifications; Circulation; Protein function; Protein structure; Chronic liver disease |
| Core Tip |
Chronic liver diseases and cirrhosis are accompanied by various metabolic disorders, some of which affect proteins. Besides changes in the concentration, structural alterations of proteins occur, mostly at the level of posttranslational modifications (PTMs). Five frequent cirrhosis-related PTMs are oxidation, nitration, glycosylation, acetylation, and ubiquitination. Some are more specific for the circulating proteins, whereas others are more specific for liver tissue-residing proteins. PTMs influence folding, stability, half-life, aggregation, and function of proteins. Modified proteins with altered function contribute to further progression of liver pathology. An overview of cirrhosis-related alterations of PTMs of specific proteins is the topic of this article. |
| Publish Date |
2022-08-03 07:54 |
| Citation |
Gligorijević N, Minić S, Nedić O. Structural changes of proteins in liver cirrhosis and consequential changes in their function. World J Gastroenterol 2022; 28(29): 3780-3792 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i29/3780.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i29.3780 |
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