| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Intracellular alpha-fetoprotein mitigates hepatocyte apoptosis and necroptosis by inhibiting endoplasmic reticulum stress
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Fen Chen, Si-Ying Liu, Qi-Jiao Cheng, Yu-Jiao Wang, Shuang Chen, Yi-Yang Zhou, Xia Liu, Zhi-Gang Jiang, Wei-Wei Zhong and Yi-Huai He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81560110 |
| Tian Qing Liver Disease Research Fund Project of the Chinese Foundation for Hepatitis Prevention and Control |
TQGB20200001 |
| Science and Technology Planning Projects of Guizhou Province and Zunyi City |
QKH·ZC[2019] 2803,QKHJC-ZK[2022]YB642, etc. |
|
| Corresponding Author |
Yi-Huai He, MM, Director, Director, Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi 563000, Guizhou Province, China. 993565989@qq.com |
| Key Words |
Alpha-fetoprotein; Endoplasmic reticulum stress; Necroptosis; Apoptosis; Liver injury |
| Core Tip |
During the process of liver injury, alpha-fetoprotein (AFP) expression was up-regulated in hepatocytes, especially in the necrotic areas, but it did not increase the serum AFP level. Endoplasmic reticulum (ER) stress induced intracellular AFP expression through activating activating transcription factor-6 and the up-regulated intracellular AFP expression attenuated hepatocyte apoptosis and necroptosis by feedback-down-regulating ER stress. |
| Publish Date |
2022-07-13 07:31 |
| Citation |
Chen YF, Liu SY, Cheng QJ, Wang YJ, Chen S, Zhou YY, Liu X, Jiang ZG, Zhong WW, He YH. Intracellular alpha-fetoprotein mitigates hepatocyte apoptosis and necroptosis by inhibiting endoplasmic reticulum stress. World J Gastroenterol 2022; 28(26): 3201-3217 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i26/3201.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i26.3201 |
