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Articles Published Processes
6/24/2022 1:12:05 PM | Browse: 509 | Download: 1590
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Received |
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2022-01-15 18:57 |
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Peer-Review Started |
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2022-01-15 18:58 |
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To Make the First Decision |
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Return for Revision |
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2022-02-07 08:35 |
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Revised |
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2022-02-21 19:38 |
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Second Decision |
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2022-05-06 02:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-05-07 00:18 |
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Articles in Press |
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2022-05-07 00:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-06-17 01:38 |
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Publish the Manuscript Online |
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2022-06-24 13:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
Downregulation of TNFR2 decreases survival gene expression, promotes apoptosis and affects the cell cycle of gastric cancer cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ana Flávia Teixeira Rossi, Fernanda da Silva Manoel-Caetano, Joice Matos Biselli, Ágata Silva Cabral, Marilia de Freitas Calmon Saiki, Marcelo Lima Ribeiro and Ana Elizabete Silva |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation (FAPESP) |
2015/21464-0 |
| São Paulo Research Foundation (FAPESP) |
2015/23392-7 |
| National Counsel of Technological and Scientific Development (CNPq) |
310120/2015-2 |
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| Corresponding Author |
Ana Elizabete Silva, PhD, Adjunct Associate Professor, Department of Biological Sciences, Sao Paulo State University (UNESP), Rua Cristóvão Colombo 2265, São José do Rio Preto 15054-000, São Paulo, Brazil. ae.silva@unesp.br |
| Key Words |
Gastric cancer; Helicobacter pylori; Tumour necrosis factor-α signalling pathway; TNFR1; TNFR2; miRNAs |
| Core Tip |
This study demonstrated for the first time the effect of TNFR1 and TNFR2 downregulation on an AGS cell line treated with Helicobacter pylori extract. Although TNFR1 downregulation did not promote significant changes in the expression of mRNA and miRNAs of the tumour necrosis factor-α (TNF-α) signalling pathway, TNFR2 downregulation promoted important changes in the signalling mediators evaluated. We observed a reduction in the expression of cell survival and anti-apoptotic genes and an increase in the expression of miR-19a and miR-34a, which affected cell cycle kinetics and contributed to early apoptosis. Thus, our findings highlight the important role of TNFR2 in the TNF-α signalling pathway in gastric carcinogenesis. |
| Publish Date |
2022-06-24 13:12 |
| Citation |
Rossi AFT, da Silva Manoel-Caetano F, Biselli JM, Cabral AS, Saiki MFC, Ribeiro ML, Silva AE. Downregulation of TNFR2 decreases survival gene expression, promotes apoptosis and affects the cell cycle of gastric cancer cells. World J Gastroenterol 2022; 28(24): 2689-2704 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i24/2689.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i24.2689 |
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