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6/24/2022 1:12:05 PM | Browse: 51 | Download: 121
Publication Name World Journal of Gastroenterology
Manuscript ID 75033
Country/Territory Brazil
Received
2022-01-15 18:57
Peer-Review Started
2022-01-15 18:58
To Make the First Decision
Return for Revision
2022-02-07 08:35
Revised
2022-02-21 19:38
Second Decision
2022-05-06 02:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-07 00:18
Articles in Press
2022-05-07 00:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-06-17 01:38
Publish the Manuscript Online
2022-06-24 13:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics and Heredity
Manuscript Type Basic Study
Article Title Downregulation of TNFR2 decreases survival gene expression, promotes apoptosis and affects the cell cycle of gastric cancer cells
Manuscript Source Invited Manuscript
All Author List Ana Flávia Teixeira Rossi, Fernanda da Silva Manoel-Caetano, Joice Matos Biselli, Ágata Silva Cabral, Marilia de Freitas Calmon Saiki, Marcelo Lima Ribeiro and Ana Elizabete Silva
ORCID
Author(s) ORCID Number
Ana Flávia Teixeira Rossi http://orcid.org/0000-0002-3476-2885
Fernanda da Silva Manoel-Caetano http://orcid.org/0000-0001-6717-5874
Joice Matos Biselli http://orcid.org/0000-0001-5105-9537
Ágata Silva Cabral http://orcid.org/0000-0002-7215-9331
Marilia de Freitas Calmon Saiki http://orcid.org/0000-0001-5203-0103
Marcelo Lima Ribeiro http://orcid.org/0000-0003-4529-7832
Ana Elizabete Silva http://orcid.org/0000-0003-1491-8878
Funding Agency and Grant Number
Funding Agency Grant Number
São Paulo Research Foundation (FAPESP) 2015/21464-0
São Paulo Research Foundation (FAPESP) 2015/23392-7
National Counsel of Technological and Scientific Development (CNPq) 310120/2015-2
Corresponding Author Ana Elizabete Silva, PhD, Adjunct Associate Professor, Department of Biological Sciences, Sao Paulo State University (UNESP), Rua Cristóvão Colombo 2265, São José do Rio Preto 15054-000, São Paulo, Brazil. ae.silva@unesp.br
Key Words Gastric cancer; Helicobacter pylori; Tumour necrosis factor-α signalling pathway; TNFR1; TNFR2; miRNAs
Core Tip This study demonstrated for the first time the effect of TNFR1 and TNFR2 downregulation on an AGS cell line treated with Helicobacter pylori extract. Although TNFR1 downregulation did not promote significant changes in the expression of mRNA and miRNAs of the tumour necrosis factor-α (TNF-α) signalling pathway, TNFR2 downregulation promoted important changes in the signalling mediators evaluated. We observed a reduction in the expression of cell survival and anti-apoptotic genes and an increase in the expression of miR-19a and miR-34a, which affected cell cycle kinetics and contributed to early apoptosis. Thus, our findings highlight the important role of TNFR2 in the TNF-α signalling pathway in gastric carcinogenesis.
Publish Date 2022-06-24 13:12
Citation Rossi AFT, da Silva Manoel-Caetano F, Biselli JM, Cabral AS, Saiki MFC, Ribeiro ML, Silva AE. Downregulation of TNFR2 decreases survival gene expression, promotes apoptosis and affects the cell cycle of gastric cancer cells. World J Gastroenterol 2022; 28(24): 2689-2704
URL https://www.wjgnet.com/1007-9327/full/v28/i24/2689.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i24.2689
Full Article (PDF) WJG-28-2689.pdf
Full Article (Word) WJG-28-2689.docx
Manuscript File 75033_Auto_Edited.docx
Answering Reviewers 75033-Answering reviewers.pdf
Audio Core Tip 75033-Audio core tip.mp3
Biostatistics Review Certificate 75033-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 75033-Conflict-of-interest statement.pdf
Copyright License Agreement 75033-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 75033-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 75033-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 75033-Language certificate.pdf
Supplementary Material 75033-Supplementary material.pdf
Peer-review Report 75033-Peer-review(s).pdf
Scientific Misconduct Check 75033-Bing-Fan JR-2.png
Scientific Editor Work List 75033-Scientific editor work list.pdf