Publication Name	World Journal of Gastroenterology
Manuscript ID	7508
Country	Romania

Received	2013-11-22 08:43
Peer-Review Started	2013-11-22 19:42
To Make the First Decision	2014-01-20 14:28
Return for Revision	2014-01-20 15:38
Revised	2014-01-25 06:32
Second Decision	2014-02-20 09:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 09:17
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-22 09:11
Publish the Manuscript Online	2014-05-07 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Ulcerative colitis worsened after Clostridium difficile infection: Efficacy of infliximab
Manuscript Source	Invited Manuscript
All Author List	Andrada Seicean, Anca Moldovan-Pop and Radu Seicean
Funding Agency and Grant Number
Corresponding Author	Andrada Seicean, MD, PhD, Regional Institute of Gastroenterology and Hepatology, Iuliu Hatieganu University of Medicine and Pharmacy, Strada Croitorilor 19-21, Cluj-Napoca 400162, Romania. andradaseicean@gmail.com
Key Words	Clostridium difficile; Ulcerative colitis; Inflammatory bowel disease; Trough level; Infliximab
Core Tip	Clostridium difficile infection (CDI) in patients with ulcerative colitis (UC) can worsen the disease and increase the risk of colectomy and death, thus requiring an escalation of treatment. This report reveals a case of UC worsened by recurrent CDI, which likely activated the patient’s immune response and stimulated the relapse of UC. Lack of response to infliximab therapy was indicated by low trough levels, and a high-dose infliximab regimen yielded better clinical results. Infliximab trough levels were found to correspond with patient outcome, and thus may serve to guide treatment in similar cases of UC with CDI.
Publish Date	2014-05-07 10:10
Citation	Seicean A, Moldovan-Pop A, Seicean R. Ulcerative colitis worsened after Clostridium difficile infection: Efficacy of infliximab. World J Gastroenterol 2014; 20(17): 5135-5140
URL	http://www.wjgnet.com/1007-9327/full/v20/i17/5135.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i17.5135

Full Article (PDF)	WJG-20-5135.pdf
Full Article (Word)	WJG-20-5135.doc
Manuscript File	7508-Review.docx
Answering Reviewers	Format for Answering Reviewers (1).docx
Copyright License Agreement	BPG Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20131121210253.jpg