Publication Name	World Journal of Gastroenterology
Manuscript ID	75091
Country	Brazil

Received	2022-01-17 00:34
Peer-Review Started	2022-01-17 00:35
To Make the First Decision
Return for Revision	2022-04-11 07:40
Revised	2022-04-19 21:45
Second Decision	2022-06-22 09:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-06-26 06:36
Articles in Press	2022-06-26 06:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-20 17:42
Typeset the Manuscript	2022-06-29 02:37
Publish the Manuscript Online	2022-07-27 02:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Noncommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Combination approaches in hepatocellular carcinoma: How systemic treatment can benefit candidates to locoregional modalities
Manuscript Source	Invited Manuscript
All Author List	Leonardo Gomes da Fonseca and Raphael L C Araujo
ORCID	Author(s) ORCID Number Leonardo Gomes da Fonseca http://orcid.org/0000-0002-0216-3618 Raphael L C Araujo http://orcid.org/0000-0002-7834-5944
Funding Agency and Grant Number
Corresponding Author	Raphael L C Araujo, MD, PhD, Adjunct Professor, Surgical Oncologist, Department of Digestive Surgery, Escola Paulista de Medicina - UNIFESP, Rua Botucatu, 740, Vila Clementino, São Paulo 04023-062, São Paulo, Brazil. raphael.l.c.araujo@gmail.com
Key Words	Liver cancer; Hepatocellular carcinoma; Immunotherapy; Systemic therapy; Ablation; Embolization
Core Tip	Management of hepatocellular carcinoma (HCC) is based on stages defined by tumor burden, liver function, and performance status. With the advent of more effective systemic treatments, such as immunotherapy and immunotherapy-based combinations, patients with advanced stage disease have better outcomes. The migration of systemic treatment to earlier stages, in combination with locoregional therapies, are expected to improve the outcomes and cure rates. Currently, the research field is moving towards an increasing interest in combining locoregional and systemic treatments for HCC.
Publish Date	2022-07-27 02:48
Citation	da Fonseca LG, Araujo RLC. Combination approaches in hepatocellular carcinoma: How systemic treatment can benefit candidates to locoregional modalities. World J Gastroenterol 2022; 28(28): 3573-3585
URL	https://www.wjgnet.com/1007-9327/full/v28/i28/3573.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i28.3573

Full Article (PDF)	WJG-28-3573.pdf
Full Article (Word)	WJG-28-3573.docx
Manuscript File	75091_Auto_Edited-YJM-Filipodia-LS.docx
Answering Reviewers	75091-Answering reviewers.pdf
Audio Core Tip	75091-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	75091-Conflict-of-interest statement.pdf
Copyright License Agreement	75091-Copyright license agreement.pdf
Peer-review Report	75091-Peer-review(s).pdf
Scientific Editor Work List	75091-Scientific editor work list.pdf
CrossCheck Report	75091-CrossCheck report.pdf