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Articles Published Processes
6/23/2022 2:39:01 PM | Browse: 420 | Download: 801
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Received |
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2022-01-17 01:48 |
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Peer-Review Started |
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2022-01-17 01:49 |
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To Make the First Decision |
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Return for Revision |
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2022-03-08 19:02 |
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Revised |
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2022-04-01 09:01 |
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Second Decision |
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2022-05-18 03:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-05-23 00:39 |
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Articles in Press |
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2022-05-23 00:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-05-13 08:38 |
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Typeset the Manuscript |
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2022-05-26 06:53 |
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Publish the Manuscript Online |
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2022-06-23 14:39 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Review |
| Article Title |
Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Iman Ibrahim Salama, Hala M Raslan, Ghada A Abdel-Latif, Somaia I Salama, Samia M Sami, Fatma A Shaaban, Aida M Abdelmohsen and Walaa A Fouad |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Iman Ibrahim Salama, MD, Professor, Department of Community Medicine Research, National Research Center, El Tahrir Street-Doki-Giza_Egypt, Giza 12622, Dokki, Egypt. salamaiman@yahoo.com |
| Key Words |
Hepatitis C virus; Hepatic; Extrahepatic; Direct-acting antivirals; Impact |
| Core Tip |
Direct-acting antivirals (DAAs) are achieving an over 85% sustained virological response in treating hepatitis C virus (HCV) infection. The risk factors for DAAs failure include old males, cirrhosis, and the presence of resistance-associated substitutions mainly in genotypes 1a and 3. The higher rate of hepatocellular carcinoma after DAA therapy may be due to offering DAA regimens to patients with advanced liver fibrosis and cirrhosis, where using interferon was contraindicated. The change in the growth of pre-existing subclinical, undetectable hepatocellular carcinoma upon DAA treatment might be a cause. DAAs are effective in treating HCV-associated mixed cryoglobulinemia, thrombocytopenia, rheumatological, renal, and cardiovascular diseases. |
| Publish Date |
2022-06-23 14:39 |
| Citation |
Salama II, Raslan HM, Abdel-Latif GA, Salama SI, Sami SM, Shaaban FA, Abdelmohsen AM, Fouad WA. Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection. World J Hepatol 2022; 14(6): 1053-1073 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i6/1053.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i6.1053 |
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