Publication Name	World Journal of Orthopedics
Manuscript ID	75179
Country	Poland

Received	2022-01-18 20:30
Peer-Review Started	2022-01-18 20:32
To Make the First Decision
Return for Revision	2022-03-24 09:32
Revised	2022-04-04 12:04
Second Decision	2022-05-06 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-05-07 00:42
Articles in Press	2022-05-07 00:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-06-05 12:27
Publish the Manuscript Online	2022-06-17 03:54

ISSN	2218-5836 (online)
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Category	Sport Sciences
Manuscript Type	Basic Study
Article Title	Content of blood cell components, inflammatory cytokines and growth factors in autologous platelet-rich plasma obtained by various methods
Manuscript Source	Unsolicited Manuscript
All Author List	Maciej Dejnek, Jarosław Witkowski, Helena Moreira, Sylwia Płaczkowska, Piotr Morasiewicz, Paweł Reichert and Aleksandra Królikowska
ORCID	Author(s) ORCID Number Maciej Dejnek http://orcid.org/0000-0002-6675-0256 Jarosław Witkowski http://orcid.org/0000-0002-2754-1339 Helena Moreira http://orcid.org/0000-0002-8084-3686 Sylwia Płaczkowska http://orcid.org/0000-0002-1466-3820 Piotr Morasiewicz http://orcid.org/0000-0002-7587-666X Paweł Reichert http://orcid.org/0000-0002-0271-4950 Aleksandra Królikowska http://orcid.org/0000-0002-6283-5500
Funding Agency and Grant Number	Funding Agency Grant Number Wroclaw Medical University as a Regional Center of Excellence in the field of medical sciences and health sciences RID.Z501.20.008
Corresponding Author	Maciej Dejnek, MD, Research Scientist, Surgeon, Department of Trauma and Hand Surgery, Wroclaw Medical University, ul. Borowska 213, Wroclaw 50-556, Poland. maciej.dejnek@student.umed.wroc.pl
Key Words	Platelet-rich plasma; Cytokines; Chemokines; Growth factors
Core Tip	The presented study showed important differences between blood cell components and levels of selected growth factors and inflammatory cytokines in platelet-rich plasma obtained with four different commercial preparation systems in a single-donor model. The range of cytokines analyzed far exceeded the ranges investigated in earlier publications. This was also the first study to pay attention to the repeatability of the quality of the obtained PRP. New positive correlations were found between platelet content in PRP and several cytokines (HGF, IL-1β, MCP-1, IL-8, IL-18). The demonstrated positive correlation between red blood cell content in PRP and cytokines has never been described before.
Publish Date	2022-06-17 03:54
Citation	Dejnek M, Witkowski J, Moreira H, Płaczkowska S, Morasiewicz P, Reichert P, Królikowska A. Content of blood cell components, inflammatory cytokines and growth factors in autologous platelet-rich plasma obtained by various methods. World J Orthop 2022; 13(6): 587-602
URL	https://www.wjgnet.com/2218-5836/full/v13/i6/587.htm
DOI	https://dx.doi.org/10.5312/wjo.v13.i6.587

Full Article (PDF)	WJO-13-587.pdf
Full Article (Word)	WJO-13-587.docx
The ARRIVE Guidelines	75179-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	75179_Auto_Edited.docx
Answering Reviewers	75179-Answering reviewers.pdf
Audio Core Tip	75179-Audio core tip.mp3
Biostatistics Review Certificate	75179-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	75179-Conflict-of-interest statement.pdf
Copyright License Agreement	75179-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	75179-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	75179-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	75179-Language certificate.pdf
Supplementary Material	75179-Supplementary material.pdf
Peer-review Report	75179-Peer-review(s).pdf
Scientific Misconduct Check	75179-Bing-Wang LL-2.png
Scientific Editor Work List	75179-Scientific editor work list.pdf
CrossCheck Report	75179-CrossCheck report.pdf