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Articles Published Processes
9/22/2022 12:23:56 PM | Browse: 222 | Download: 841
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Received |
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2022-01-20 10:33 |
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Peer-Review Started |
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2022-01-20 10:34 |
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To Make the First Decision |
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Return for Revision |
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2022-04-12 01:56 |
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Revised |
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2022-04-22 08:36 |
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Second Decision |
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2022-08-22 03:09 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-25 21:02 |
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Articles in Press |
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2022-08-25 21:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-08-08 13:51 |
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Typeset the Manuscript |
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2022-09-16 08:07 |
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Publish the Manuscript Online |
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2022-09-22 12:23 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Observational Study |
| Article Title |
Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Wang, Zhen-Feng Deng, Ji-Long Wang, Ling Zhang, Li Bao, Bang-Hao Xu, Hai Zhu, Ya Guo and Zhang Wen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
8190111624 |
| Guangxi Natural Science Foundation of China |
2018JJB140382 |
| Guangxi University Young and Middle-Aged Teachers’ Basic Scientific Research Ability Improvement Project |
2019KY0123 |
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| Corresponding Author |
Zhang Wen, MD, PhD, Chief Doctor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6, Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. wenzgxmu@163.com |
| Key Words |
Associating liver partition and portal vein ligation for staged hepatectomy; Tumor-infiltrating lymphocytes; Multiplexed immunohistochemistry; Tumor necrosis |
| Core Tip |
This study was conducted to evaluate the feasibility of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for massive hepatocellular carcinoma by exploring the role of tumor-infiltrating lymphocyte (TIL) subpopulations in the tumor microenvironment. The ALPPS procedure did not cause severe immunosuppression due to reduced TIL infiltration and pathological alterations in peripheral blood immune components. In addition, high perioperative CD8+ T cell infiltration with ALPPS was associated with increased tumor necrosis. |
| Publish Date |
2022-09-22 12:23 |
| Citation |
Wang W, Deng ZF, Wang JL, Zhang L, Bao L, Xu BH, Zhu H, Guo Y, Wen Z. Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma. World J Gastrointest Surg 2022; 14(9): 1008-1025 |
| URL |
https://www.wjgnet.com/1948-9366/full/v14/i9/1008.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v14.i9.1008 |
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