Publication Name	World Journal of Hepatology
Manuscript ID	75254
Country	Mexico

Received	2022-01-21 01:00
Peer-Review Started	2022-01-21 01:01
First Decision by Editorial Office Director	2022-06-07 06:58
Return for Revision	2022-06-07 06:58
Revised	2022-06-20 14:24
Publication Fee Transferred
Second Decision by Editor	2022-07-04 03:03
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-07-06 04:40
Articles in Press	2022-07-06 04:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-18 00:32
Publish the Manuscript Online	2022-07-27 13:17

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans
Manuscript Source	Invited Manuscript
All Author List	Rafael Torres-Valadez, Sonia Roman, Claudia Ojeda-Granados, Karina Gonzalez-Aldaco and Arturo Panduro
ORCID	Author(s) ORCID Number Rafael Torres-Valadez http://orcid.org/0000-0001-7089-4343 Sonia Roman http://orcid.org/0000-0001-7061-6634 Claudia Ojeda-Granados http://orcid.org/0000-0001-9734-558X Karina Gonzalez-Aldaco http://orcid.org/0000-0001-5129-3307 Arturo Panduro http://orcid.org/0000-0003-4784-748X
Funding Agency and Grant Number
Corresponding Author	Arturo Panduro, FAASLD, MD, PhD, Research Scientist, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences Center, University of Guadalajara, Hospital # 278 Col. El Retiro, Guadalajara 44280, Jalisco, Mexico. apanduro@prodigy.net.mx
Key Words	Dyslipidemia; Ethnicity; Genes; Obesity; Lipids; Liver disease; Diet
Core Tip	Dyslipidemia is a metabolic alteration caused by gene-environmental interactions influenced by ethnicity. Genetic polymorphisms can modify the frequency and outcome of the hyperlipidemic state. Our results showed a differential distribution of gene polymorphisms associated with hypercholesterolemia (APOE4, LDLR), hypertriglyceridemia (APOE2, MTTP), and hypoalphalipoproteinemia (ABCA1) among Native Americans and Mestizo Mexicans of West Mexico. Hypercholesterolemia was the predominant dyslipidemia. In normal weight subjects, the APOB TT and LDLR GG genotypes increased the risk for hypercholesterolemia in the context of the Mestizo ethnicity. Regional personalized-medicine prevention strategies based on the host's genetic and environmental factors are required to decrease the prevalence of dyslipidemias.
Publish Date	2022-07-27 13:17
Citation	Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K, Panduro A. Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans. World J Hepatol 2022; 14(7): 1408-1420
URL	https://www.wjgnet.com/1948-5182/full/v14/i7/1408.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i7.1408

Full Article (PDF)	WJH-14-1408.pdf
Full Article (Word)	WJH-14-1408.docx