Publication Name	World Journal of Gastroenterology
Manuscript ID	7529
Country	China

Received	2013-11-23 09:00
Peer-Review Started	2013-11-23 17:39
To Make the First Decision	2013-12-26 10:59
Return for Revision	2013-12-27 20:57
Revised	2014-01-19 22:46
Second Decision	2014-02-20 09:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-02-20 09:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-18 22:19
Typeset the Manuscript	2014-04-22 08:57
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Protective effect of glutamine on intestinal injury and bacterial community in rats exposed to hypobaric hypoxia environment
Manuscript Source	Invited Manuscript
All Author List	Chun-Lan Xu, Rui Sun, Xiang-Jin Qiao, Cui-Cui Xu, Xiao-Ya Shang and Wei-Ning Niu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31001012 National Natural Science Foundation of China 31101304 Programs for Agricultural Science and Technology Development of Shaanxi Province, China 2013K02-16 Northwestern Polytechnical University Foundation Science Research Fund JC201278
Corresponding Author	Chun-Lan Xu, Associate Professor, The Key Laboratory for Space Bioscience and Biotechnology, School Life Sciences, Northwestern Polytechnical University, 127 Youyixi Road, Xi’an 710072, Shaanxi province, China. clxu@nwpu.edu.cn
Key Words	Hypobaric hypoxia; Glutamine; Intestinal mucosa; Immunomodulation; Bacterial community
Core Tip	Gastrointestinal problems at high altitudes are common. Gut microbes may also play an important role in host health. Glutamine has been demonstrated to be an important source of fuel for the gut. In the study, we investigated the protective effect of glutamine on intestinal barrier damage induced by hypobaric hypoxia. The research provides a basic understanding of possible mechanism of hypobaric hypoxia-induced damage of intestinal barrier function and bacterial community imbalance. The altered bacterial communities in the intestine and the toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB signal pathway may represent the significant therapeutic targets for the prevention/treatment of intestinal barrier dysfunction and consequent intestinal diseases.
Publish Date	2014-04-29 09:53
Citation	Xu CL, Sun R, Qiao XJ, Xu CC, Shang XY, Niu WN. Protective effect of glutamine on intestinal injury and bacterial community in rats exposed to hypobaric hypoxia environment. World J Gastroenterol 2014; 20(16): 4662-4674
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4662.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4662

Full Article (PDF)	WJG-20-4662.pdf
Full Article (Word)	WJG-20-4662.doc
Manuscript File	7529-Review.doc
Answering Reviewers	7529-Answering reviewers.pdf
Copyright License Agreement	7529-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7529-Language certificate.pdf
Peer-review Report	7529-Peer reviews.pdf
Scientific Editor Work List	7529-Scientific editor work list.doc