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Articles Published Processes
8/10/2022 8:23:14 AM | Browse: 357 | Download: 720
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Received |
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2022-01-24 10:48 |
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Peer-Review Started |
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2022-01-24 10:50 |
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To Make the First Decision |
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Return for Revision |
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2022-04-10 22:00 |
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Revised |
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2022-04-21 13:35 |
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Second Decision |
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2022-07-15 03:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-18 21:37 |
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Articles in Press |
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2022-07-18 21:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-07-08 03:34 |
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Typeset the Manuscript |
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2022-07-29 09:23 |
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Publish the Manuscript Online |
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2022-08-10 08:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive procedures
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Paolo Gallo, Francesca Terracciani, Giulia Di Pasquale, Matteo Esposito, Antonio Picardi and Umberto Vespasiani-Gentilucci |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Paolo Gallo, MD, Associate Research Scientist, Doctor, Doctor, Clinical Medicine and Hepatology Unit, Campus Bio-Medico University, Via Alvaro del Portillo, 200, Roma 00128, Italy. paolo.gallo@policlinicocampus.it |
| Key Words |
Thrombocytopenia; Chronic liver disease; Thrombopoietin agonists; Platelet transfusions; Avatrombopag; Lusutrombopag |
| Core Tip |
Recent advances have shed light on the pathophysiology of thrombocytopenia in chronic liver disease and on the key role of thrombopoietin (TPO). Severe thrombocytopenia complicates the management of patients with liver disease by increasing the potential risk of bleeding for invasive procedures, possibly delaying lifesaving interventions. In the very last years, novel agents such as the TPO-receptor agonists avatrombopag and lusutrombopag have been developed in order to increase platelet production as an alternative to platelet transfusions, with positive efficacy and safety outcomes. |
| Publish Date |
2022-08-10 08:23 |
| Citation |
Gallo P, Terracciani F, Di Pasquale G, Esposito M, Picardi A, Vespasiani-Gentilucci U. Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive procedures. World J Gastroenterol 2022; 28(30): 4061-4074 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i30/4061.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i30.4061 |
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