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Articles Published Processes
8/26/2022 7:50:06 AM | Browse: 518 | Download: 1211
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Received |
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2022-01-27 16:13 |
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Peer-Review Started |
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2022-01-27 16:15 |
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To Make the First Decision |
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Return for Revision |
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2022-04-10 21:01 |
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Revised |
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2022-04-23 14:30 |
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Second Decision |
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2022-08-03 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-06 23:41 |
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Articles in Press |
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2022-08-06 23:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-08-18 08:45 |
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Publish the Manuscript Online |
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2022-08-26 07:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Colon mucus in colorectal neoplasia and beyond
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alexandre Loktionov |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Alexandre Loktionov, MD, PhD, Director, Director, N/A, DiagNodus Ltd, St John’s Innovation Centre, Cowley Road, Cambridge CB4 0WS, United Kingdom. alex.loktionov@diagnodus.com |
| Key Words |
Colon; Colon mucus; Mucins; Goblet cells; Gut microbiota; Inflammatory bowel disease; Colorectal cancer |
| Core Tip |
Until recently colon mucus (CM) importance was largely ignored because its structure and functions were obscure. It is now known that human CM comprises a dense inner layer impenetrable for bacteria and a loose outer layer providing a habitat for abundant commensal microbiota. Mucus barrier integrity is essential for maintaining homeostatic balance between colonic mucosa and gut microbiota, and its impairment opens direct bacterial access to the epithelium, which induces inflammation and can cause severe disorders, including inflammatory bowel disease and colorectal cancer. Recent advances in colorectal mucus exploration and emerging new clinical applications based on this knowledge are discussed. |
| Publish Date |
2022-08-26 07:50 |
| Citation |
Loktionov A. Colon mucus in colorectal neoplasia and beyond. World J Gastroenterol 2022; 28(32): 4475-4492 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i32/4475.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i32.4475 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
