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Articles Published Processes
8/3/2022 7:54:39 AM | Browse: 544 | Download: 1551
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Received |
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2022-01-28 11:16 |
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Peer-Review Started |
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2022-01-28 11:18 |
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To Make the First Decision |
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Return for Revision |
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2022-04-10 20:32 |
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Revised |
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2022-05-20 08:36 |
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Second Decision |
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2022-07-11 02:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-11 16:06 |
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Articles in Press |
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2022-07-11 16:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-07-03 21:38 |
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Typeset the Manuscript |
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2022-07-25 02:52 |
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Publish the Manuscript Online |
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2022-08-03 07:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Juliane Malik, Martin Klammer, Vinzent Rolny, Henry Lik-Yuen Chan, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Köhler and Magdalena Swiatek-de Lange |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Juliane Malik, PhD, N/A, N/A, N/A, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg 82377, Germany. juliane.malik@roche.com |
| Key Words |
Carcinoma; Hepatocellular; MicroRNAs; Biomarkers; Alpha-fetoprotein; Protein induced by vitamin K absence-II; Diagnosis |
| Core Tip |
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a high mortality rate, making early diagnosis essential for better treatment outcomes. Studies have shown microRNAs to be early markers for HCC; we evaluated the potential diagnostic role of microRNAs alone and in combination with known protein biomarkers (alpha-fetoprotein, protein induced by vitamin K absence/antagonist-II) in samples from HCC-affected individuals and controls using real-time quantitative PCR and next-generation sequencing. MiR-21 and miR-423 demonstrated significant differential expression between the HCC and control groups. MicroRNAs alone or as a signature in combination with protein biomarkers did not improve diagnostic performance of the protein biomarkers. |
| Publish Date |
2022-08-03 07:54 |
| Citation |
Malik J, Klammer M, Rolny V, Chan HLY, Piratvisuth T, Tanwandee T, Thongsawat S, Sukeepaisarnjaroen W, Esteban JI, Bes M, Köhler B, Swiatek-de Lange M. Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma. World J Gastroenterol 2022; 28(29): 3917-3933 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i29/3917.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i29.3917 |
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