BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/24/2022 9:00:24 AM | Browse: 317 | Download: 951
 |
Received |
|
2022-02-01 13:52 |
|
Peer-Review Started |
|
2022-02-01 13:53 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2022-03-15 08:18 |
|
Revised |
|
2022-03-21 05:24 |
|
Second Decision |
|
2022-04-08 02:16 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2022-04-09 18:26 |
|
Articles in Press |
|
2022-04-09 18:26 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2022-06-15 10:52 |
|
Publish the Manuscript Online |
|
2022-06-24 09:00 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Intestinal mucosal barrier in functional constipation: Dose it change?
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Ke Wang, Wei Wei, Dong-Yan Zhao, Hui-Fen Wang, Yan-Li Zhang, Jie-Ping Lei and Shu-Kun Yao |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Shu-Kun Yao, MD, PhD, Doctor, Doctor, Professor, Graduate school, Peking Union Medical College and Chinese Academy of Medical Sciences, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China, Beijing 100730, China. shukunyao@126.com |
| Key Words |
Intestinal mucosal barrier; Functional constipation; Goblet cells; Intercellular junctions; Mucosal immunity; Gut permeability |
| Core Tip |
The present study investigated the intestinal mucosal barrier in functional constipation (FC) patients for the first time, including the mucus barrier, the intestinal epithelial barrier, the mucosal immune state and gut permeability. FC patients exhibited a significant increase in goblet cells and integral intercellular junctional complexes. There were no significant alterations in the localization and expression of occludin and zonula occludens-1 in FC patients. No significant increase in CD3+ intraepithelial lymphocytes, CD3+ lamina propria lymphocytes, serum D-lactic acid or zonulin levels was found in FC patients, which indicated no mucosal immune activation or increased gut permeability. |
| Publish Date |
2022-06-24 09:00 |
| Citation |
Wang JK, Wei W, Zhao DY, Wang HF, Zhang YL, Lei JP, Yao SK. Intestinal mucosal barrier in functional constipation: Dose it change? World J Clin Cases 2022; 10(19): 6385-6398 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i19/6385.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i19.6385 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
