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Articles Published Processes
7/11/2022 5:53:38 AM | Browse: 446 | Download: 956
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Received |
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2022-02-01 15:10 |
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Peer-Review Started |
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2022-02-01 15:12 |
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To Make the First Decision |
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Return for Revision |
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2022-04-18 00:04 |
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Revised |
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2022-04-19 16:00 |
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Second Decision |
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2022-06-21 03:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-26 23:48 |
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Articles in Press |
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2022-06-26 23:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-05 14:21 |
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Publish the Manuscript Online |
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2022-07-11 05:53 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Review |
| Article Title |
Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
María M Adeva-Andany and Natalia Carneiro-Freire |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
María M Adeva-Andany, MD, PhD, Consultant Physician-Scientist, Nephrology, Hospital Juan Cardona, Pardo Bazán x/n, Ferrol 15406, Spain. madevaa@yahoo.com |
| Key Words |
Diabetes; Kidney disease; Glycosaminoglycans; Factor H; Sialic acid; Laminin; Collagen; Fibronectin-1; Extracellular matrix |
| Core Tip |
Diabetic kidney disease is associated with profound disturbance in glomerular extracellular matrix (ECM). Understanding the mechanisms that regulate glomerular ECM synthesis and repair may contribute to design therapeutic strategies that improve clinical outcomes. The cytoskeleton inside the foot processes of podocytes is connected to the glomerular basement membrane (GBM) via associated proteins. There is a reciprocal interaction between the cellular cytoskeleton and the extracellular tissue that contribute to regulate ECM composition. Loss of anchor points in the GBM may lead to podocyte detachment. Likewise, alterations in the podocyte cytoskeleton may unfasten the cell and impair the filtration barrier. |
| Publish Date |
2022-07-11 05:53 |
| Citation |
Adeva-Andany MM, Carneiro-Freire N. Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease. World J Diabetes 2022; 13(7): 498-520 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i7/498.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i7.498 |
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