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Articles Published Processes
7/18/2022 9:47:46 AM | Browse: 492 | Download: 983
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Received |
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2022-02-02 11:28 |
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Peer-Review Started |
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2022-02-02 11:29 |
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To Make the First Decision |
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Return for Revision |
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2022-04-10 20:00 |
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Revised |
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2022-04-24 18:51 |
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Second Decision |
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2022-06-15 02:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-16 16:33 |
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Articles in Press |
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2022-06-16 16:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-06-23 10:21 |
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Publish the Manuscript Online |
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2022-07-18 09:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma: Current evidence and future perspectives
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Masayuki Ueno, Haruhiko Takeda, Atsushi Takai and Hiroshi Seno |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Atsushi Takai, MD, PhD, Assistant Professor, Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 6068507, Japan. atsushit@kuhp.kyoto-u.ac.jp |
| Key Words |
Nonalcoholic fatty liver disease; Hepatocellular carcinoma; Risk factors; Biomarkers; Tumor markers; Genetics |
| Core Tip |
This review summarizes the risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC). The highlighted risk factors include liver fibrosis, diabetes, age, sex, race, alcohol intake, elevated liver enzymes, and specific genetic variants. Currently available diagnostic biomarkers include alpha-fetoprotein (AFP), des-carboxyprothrombin, and the AFP isoform L3. The combined use of these biomarkers may increase the diagnostic sensitivity of NAFLD-HCC detection. However, more discussion will be necessary on the cost-effectiveness of these approaches. This review also summarizes emerging means of discovering novel biomarkers using omics techniques. A better understanding of these risk factors and diagnostic biomarkers will facilitate the effective surveillance of NAFLD-HCC. |
| Publish Date |
2022-07-18 09:47 |
| Citation |
Ueno M, Takeda H, Takai A, Seno H. Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma: Current evidence and future perspectives. World J Gastroenterol 2022; 28(27): 3410-3421 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i27/3410.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i27.3410 |
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