BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/18/2022 9:47:46 AM | Browse: 772 | Download: 1829
 |
Received |
|
2022-02-02 11:28 |
|
Peer-Review Started |
|
2022-02-02 11:29 |
|
First Decision by Editorial Office Director |
|
2022-04-10 20:00 |
|
Return for Revision |
|
2022-04-10 20:00 |
|
Revised |
|
2022-04-24 18:51 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2022-06-15 02:57 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2022-06-16 16:33 |
|
Articles in Press |
|
2022-06-16 16:33 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2022-06-23 10:21 |
|
Publish the Manuscript Online |
|
2022-07-18 09:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma: Current evidence and future perspectives
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Masayuki Ueno, Haruhiko Takeda, Atsushi Takai and Hiroshi Seno |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Atsushi Takai, MD, PhD, Assistant Professor, Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 6068507, Japan. atsushit@kuhp.kyoto-u.ac.jp |
| Key Words |
Nonalcoholic fatty liver disease; Hepatocellular carcinoma; Risk factors; Biomarkers; Tumor markers; Genetics |
| Core Tip |
This review summarizes the risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC). The highlighted risk factors include liver fibrosis, diabetes, age, sex, race, alcohol intake, elevated liver enzymes, and specific genetic variants. Currently available diagnostic biomarkers include alpha-fetoprotein (AFP), des-carboxyprothrombin, and the AFP isoform L3. The combined use of these biomarkers may increase the diagnostic sensitivity of NAFLD-HCC detection. However, more discussion will be necessary on the cost-effectiveness of these approaches. This review also summarizes emerging means of discovering novel biomarkers using omics techniques. A better understanding of these risk factors and diagnostic biomarkers will facilitate the effective surveillance of NAFLD-HCC. |
| Publish Date |
2022-07-18 09:47 |
| Citation |
Ueno M, Takeda H, Takai A, Seno H. Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma: Current evidence and future perspectives. World J Gastroenterol 2022; 28(27): 3410-3421 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i27/3410.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i27.3410 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
