Publication Name	World Journal of Gastroenterology
Manuscript ID	7555
Country	Japan

Received	2013-12-10 16:20
Peer-Review Started	2013-12-10 17:07
To Make the First Decision	2014-01-09 16:15
Return for Revision	2014-01-17 08:40
Revised	2014-01-28 18:30
Second Decision	2014-03-05 14:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-05 14:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-16 10:53
Publish the Manuscript Online	2014-07-03 15:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Fibrogenesis in alcoholic liver disease
Manuscript Source	Invited Manuscript
All Author List	Hideki Fujii and Norifumi Kawada
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science (JSPS) 25293177 (to Kawada N) (2013-2016) JSPS 25461007 (to Fujii H) (2013-2016)
Corresponding Author	Norifumi Kawada, MD, PhD, Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno, Osaka 545-8585, Japan. kawadanori@med.osaka-cu.ac.jp
Key Words	Stellate cell; Kupffer cell; Steatohepatitis; Fibrosis; Cytokine; Oxidative stress
Core Tip	Alcoholic liver disease (ALD) is a major cause of preventable morbidity and mortality worldwide. In ALD-associated fibrosis, hepatic stellate cells are the principal cell type responsible for extracellular matrix production. Although the mechanisms underlying ALD-associated fibrosis are largely similar to those observed in other chronic liver diseases, oxidative stress, abnormal methionine metabolism, hepatocyte apoptosis, and endotoxin lipopolysaccharides that activate Kupffer cells play unique roles in fibrogenesis in ALD. Recently, lipogenesis during the early stages of ALD has been implicated as a risk factor for progression of cirrhosis. Other critical factors include osteopontin, interleukin-1 signaling, and genetic polymorphisms.
Publish Date	2014-07-03 15:30
Citation	Fujii H, Kawada N. Fibrogenesis in alcoholic liver disease. World J Gastroenterol 2014; 20(25): 8048-8054
URL	http://www.wjgnet.com/1007-9327/full/v20/i25/8048.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i25.8048

Full Article (PDF)	WJG-20-8048.pdf
Full Article (Word)	WJG-20-8048.doc
Manuscript File	7555-Review.docx
Answering Reviewers	7555-Answering reviewers.pdf
Copyright License Agreement	7555-Copyright assignmentt.pdf
Peer-review Report	7555-Peer review(s).pdf
Scientific Editor Work List	7555-Scientific editor work list.doc