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Articles Published Processes
10/28/2022 12:37:03 PM | Browse: 427 | Download: 1538
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Received |
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2022-02-06 16:47 |
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Peer-Review Started |
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2022-02-06 16:50 |
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To Make the First Decision |
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Return for Revision |
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2022-04-10 08:29 |
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Revised |
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2022-05-06 20:18 |
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Second Decision |
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2022-06-06 03:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-17 21:20 |
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Articles in Press |
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2022-06-17 21:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-06-04 01:43 |
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Typeset the Manuscript |
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2022-10-24 04:25 |
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Publish the Manuscript Online |
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2022-10-28 12:37 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mohammad El-Harakeh, Jessica Saliba, Kawthar Sharaf Aldeen, May Haidar, Layal El Hajjar, Mireille Kallassy Awad, Jana G Hashash, Margret Shirinian and Marwan El-Sabban |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marwan El-Sabban, PhD, Professor, Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Bliss Street, Beirut 1107, Lebanon. me00@aub.edu.lb |
| Key Words |
Demethylation; Inflammation-induced carcinogenesis; Ulcerative colitis; Colorectal cancer; Connexins |
| Core Tip |
Chronic inflammation of the colon is a risk factor for colorectal cancer. Intestinal inflammation has been associated with reduced gap junction-mediated intercellular communication and downregulation connexins [mainly connexin 43 (Cx43)]. The involvement of the demethylating enzyme ten-eleven translocation-2 (TET-2) (methylcytosine dioxygenase) in the inflammatory process has motivated the investigation of Cx43 and TET-2 expression in colitis and colorectal carcinoma. In vitro and in vivo data report on the upregulation of Cx43 in inflammatory states and a downregulation of TET-2. In human samples of colon adenocarcinoma, both TET-2 and Cx43 were downregulated, potentially implicating them in the malignant transformation of inflamed intestinal tissues. |
| Publish Date |
2022-10-28 12:37 |
| Citation |
El-Harakeh M, Saliba J, Sharaf Aldeen K, Haidar M, El Hajjar L, Awad MK, Hashash JG, Shirinian M, El-Sabban M. Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer. World J Gastroenterol 2022;28(40): 5845-5864 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i40/5845.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i40.5845 |
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