BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/28/2022 12:37:03 PM | Browse: 256 | Download: 919
Publication Name World Journal of Gastroenterology
Manuscript ID 75596
Country/Territory Lebanon
Received
2022-02-06 16:47
Peer-Review Started
2022-02-06 16:50
To Make the First Decision
Return for Revision
2022-04-10 08:29
Revised
2022-05-06 20:18
Second Decision
2022-06-06 03:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-06-17 21:20
Articles in Press
2022-06-17 21:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-06-04 01:43
Typeset the Manuscript
2022-10-24 04:25
Publish the Manuscript Online
2022-10-28 12:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Mohammad El-Harakeh, Jessica Saliba, Kawthar Sharaf Aldeen, May Haidar, Layal El Hajjar, Mireille Kallassy Awad, Jana G Hashash, Margret Shirinian and Marwan El-Sabban
ORCID
Author(s) ORCID Number
Mohammad El-Harakeh http://orcid.org/0000-0003-3014-3937
Jessica Saliba http://orcid.org/0000-0002-9117-8773
Kawthar Sharaf Aldeen http://orcid.org/0000-0002-9546-104X
May Haidar http://orcid.org/0000-0002-4345-0621
Layal El Hajjar http://orcid.org/0000-0003-3123-5577
Mireille Kallassy Awad http://orcid.org/0000-0003-1489-8686
Jana G Hashash http://orcid.org/0000-0001-8305-9742
Margret Shirinian http://orcid.org/0000-0003-4666-2758
Marwan El-Sabban http://orcid.org/0000-0001-5084-7654
Funding Agency and Grant Number
Corresponding Author Marwan El-Sabban, PhD, Professor, Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Bliss Street, Beirut 1107, Lebanon. me00@aub.edu.lb
Key Words Demethylation; Inflammation-induced carcinogenesis; Ulcerative colitis; Colorectal cancer; Connexins
Core Tip Chronic inflammation of the colon is a risk factor for colorectal cancer. Intestinal inflammation has been associated with reduced gap junction-mediated intercellular communication and downregulation connexins [mainly connexin 43 (Cx43)]. The involvement of the demethylating enzyme ten-eleven translocation-2 (TET-2) (methylcytosine dioxygenase) in the inflammatory process has motivated the investigation of Cx43 and TET-2 expression in colitis and colorectal carcinoma. In vitro and in vivo data report on the upregulation of Cx43 in inflammatory states and a downregulation of TET-2. In human samples of colon adenocarcinoma, both TET-2 and Cx43 were downregulated, potentially implicating them in the malignant transformation of inflamed intestinal tissues.
Publish Date 2022-10-28 12:37
Citation El-Harakeh M, Saliba J, Sharaf Aldeen K, Haidar M, El Hajjar L, Awad MK, Hashash JG, Shirinian M, El-Sabban M. Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer. World J Gastroenterol 2022;28(40): 5845-5864
URL https://www.wjgnet.com/1007-9327/full/v28/i40/5845.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i40.5845
Full Article (PDF) WJG-28-5845.pdf
Full Article (Word) WJG-28-5845.docx
Manuscript File 75596_Auto_Edited-JRF-Filipodia CL.docx
Answering Reviewers 75596-Answering reviewers.pdf
Audio Core Tip 75596-Audio core tip.ogg
Biostatistics Review Certificate 75596-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 75596-Conflict-of-interest statement.pdf
Copyright License Agreement 75596-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 75596-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 75596-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 75596-Language certificate.pdf
Supplementary Material 75596-Supplementary material.pdf
Peer-review Report 75596-Peer-review(s).pdf
Scientific Misconduct Check 75596-Bing-Fan JR-2.png
Scientific Editor Work List 75596-Scientific editor work list.pdf