| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
RING finger and WD repeat domain 3 regulates proliferation and metastasis through the Wnt/β-catenin signalling pathways in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ruo-Peng Liang, Xiao-Xue Zhang, Jie Zhao, Qin-Wei Lu, Rong-Tao Zhu, Wei-Jie Wang, Jian Li, Kai Bo, Chi-Xian Zhang and Yu-Ling Sun |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82172944 |
| National Natural Science Foundation of China |
81900558 |
| Co-operation Research Plan of Medical Science and Technology of Henan Province |
LHGJ20190149 |
| The Key Scientific Research Projects of Universities of Henan Province |
21A320052 |
|
| Corresponding Author |
Yu-Ling Sun, MD, PhD, Chief Doctor, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, No. 50 West Jianshe Road, Zhengzhou 450052, Henan Province, China. ylsun@zzu.edu.cn |
| Key Words |
RING finger and WD repeat domain 3; Hepatocellular carcinoma; Invasion; Proliferation; Metastasis; Wnt/β-catenin signaling pathways |
| Core Tip |
The relationship between RING finger and WD repeat domain 3 (RFWD3) and tumorigenesis process has been reported occasionally, but the relationship between RFWD3 and hepatocellular carcinoma (HCC) is still unclear. This research reports the significant role of RFWD3 in HCC development by using bioinformatics databases, clinical samples, cell phenotypes, in vivo experiments, and microarray analyses. It provides evidence that RFWD3 expression might affect the tumorigenesis process of HCC by regulating the Wnt/β-catenin signalling pathways, laying a basic foundation for future relevant studies. |
| Publish Date |
2022-07-18 09:47 |
| Citation |
Liang RP, Zhang XX, Zhao J, Lu QW, Zhu RT, Wang WJ, Li J, Bo K, Zhang CX, Sun YL. RING finger and WD repeat domain 3 regulates proliferation and metastasis through the Wnt/β-catenin signalling pathways in hepatocellular carcinoma. World J Gastroenterol 2022; 28(27): 3435-3454 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i27/3435.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i27.3435 |
