Publication Name	World Journal of Gastroenterology
Manuscript ID	75609
Country	China

Received	2022-02-07 03:43
Peer-Review Started	2022-02-07 03:45
To Make the First Decision
Return for Revision	2022-04-05 21:14
Revised	2022-04-16 07:16
Second Decision	2022-05-30 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-06-03 21:05
Articles in Press	2022-06-03 21:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-13 02:48
Publish the Manuscript Online	2022-07-18 09:47

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	RING finger and WD repeat domain 3 regulates proliferation and metastasis through the Wnt/β-catenin signalling pathways in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Ruo-Peng Liang, Xiao-Xue Zhang, Jie Zhao, Qin-Wei Lu, Rong-Tao Zhu, Wei-Jie Wang, Jian Li, Kai Bo, Chi-Xian Zhang and Yu-Ling Sun
ORCID	Author(s) ORCID Number Ruo-Peng Liang http://orcid.org/0000-0002-3789-1666 Xiao-Xue Zhang http://orcid.org/0000-0003-2272-3405 Jie Zhao http://orcid.org/0000-0001-7701-1654 Qin-Wei Lu http://orcid.org/0000-0003-3801-8217 Rong-Tao Zhu http://orcid.org/0000-0003-3655-9458 Wei-Jie Wang http://orcid.org/0000-0003-3136-8628 Jian Li http://orcid.org/0000-0001-7756-2312 Kai Bo http://orcid.org/0000-0002-0039-0585 Chi-Xian Zhang http://orcid.org/0000-0002-4387-7182 Yu-Ling Sun http://orcid.org/0000-0001-5289-4673
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82172944 National Natural Science Foundation of China 81900558 Co-operation Research Plan of Medical Science and Technology of Henan Province LHGJ20190149 The Key Scientific Research Projects of Universities of Henan Province 21A320052
Corresponding Author	Yu-Ling Sun, MD, PhD, Chief Doctor, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, No. 50 West Jianshe Road, Zhengzhou 450052, Henan Province, China. ylsun@zzu.edu.cn
Key Words	RING finger and WD repeat domain 3; Hepatocellular carcinoma; Invasion; Proliferation; Metastasis; Wnt/β-catenin signaling pathways
Core Tip	The relationship between RING finger and WD repeat domain 3 (RFWD3) and tumorigenesis process has been reported occasionally, but the relationship between RFWD3 and hepatocellular carcinoma (HCC) is still unclear. This research reports the significant role of RFWD3 in HCC development by using bioinformatics databases, clinical samples, cell phenotypes, in vivo experiments, and microarray analyses. It provides evidence that RFWD3 expression might affect the tumorigenesis process of HCC by regulating the Wnt/β-catenin signalling pathways, laying a basic foundation for future relevant studies.
Publish Date	2022-07-18 09:47
Citation	Liang RP, Zhang XX, Zhao J, Lu QW, Zhu RT, Wang WJ, Li J, Bo K, Zhang CX, Sun YL. RING finger and WD repeat domain 3 regulates proliferation and metastasis through the Wnt/β-catenin signalling pathways in hepatocellular carcinoma. World J Gastroenterol 2022; 28(27): 3435-3454
URL	https://www.wjgnet.com/1007-9327/full/v28/i27/3435.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i27.3435

Full Article (PDF)	WJG-28-3435.pdf
Full Article (Word)	WJG-28-3435.docx
The ARRIVE Guidelines	75609-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	75609_Auto_Edited-LS.docx
Answering Reviewers	75609-Answering reviewers.pdf
Audio Core Tip	75609-Audio core tip.m4a
Biostatistics Review Certificate	75609-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	75609-Conflict-of-interest statement.pdf
Copyright License Agreement	75609-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	75609-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	75609-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	75609-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	75609-Language certificate.pdf
Supplementary Material	75609-Supplementary material.rar
Peer-review Report	75609-Peer-review(s).pdf
Scientific Misconduct Check	75609-Bing-Fan JR-2.png
Scientific Editor Work List	75609-Scientific editor work list.pdf
CrossCheck Report	75609-CrossCheck report.pdf
CrossCheck Report	75609-CrossCheck.png