Publication Name	World Journal of Methodology
Manuscript ID	7561
Country	Italy

Received	2013-11-25 14:37
Peer-Review Started	2013-11-25 21:30
To Make the First Decision	2013-12-25 18:11
Return for Revision	2013-12-26 20:23
Revised	2014-01-28 01:39
Second Decision	2014-04-17 14:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-17 15:08
Articles in Press	2014-05-23 12:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-14 08:31
Typeset the Manuscript	2014-07-08 20:35
Publish the Manuscript Online	2014-08-20 20:59

ISSN	2222-0682 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Review
Article Title	Novel agents and new therapeutic approaches for treatment of multiple myeloma
Manuscript Source	Invited Manuscript
All Author List	Roberto Ria, Antonia Reale and Angelo Vacca
Funding Agency and Grant Number	Funding Agency Grant Number Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research-AIRC) Investigator Grant 5 per thousand Molecular Clinical Oncology Special Program 9965 European Commission's Seventh Framework programme (EU-FPT7) under grant agreement (OVER-MyR) 278706(to AV) EU FPT7 (2007-2013) 278570(to DR) MIUR PRIN 2009WCNS5C_004(to RR) MIUR PRIN 2010NECHBX( to AV)
Corresponding Author	Roberto Ria, MD, Section of Internal Medicine, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, I-70124 Bari, Italy. roberto.ria@uniba.it
Key Words	Immunomodulators; Multiple myeloma; New drugs; Proteasome inhibitors; Target therapy
Core Tip	The aim of this review is to summarize and point out the current therapeutic strategies and the drugs actually in development for the management of multiple myeloma. The rationale of the new treatment strategies is found in their efficacy in targeting tumor cells and their microenvironment. Our understanding of multiple myeloma (MM) pathogenesis including the intracellular mechanisms as well as the interactions between MM cells and their microenvironment has helped the discovery of several targets that have become the focus of drug development. The goal is to improve patient’s survival and to control the disease in a long-term fashion, maintaining the quality of life of our patients.
Publish Date	2014-08-20 20:59
Citation	Ria R, Reale A, Vacca A. Novel agents and new therapeutic approaches for treatment of multiple myeloma. World J Methodol 2014; 4(2): 73-90
URL	http://www.wjgnet.com/2222-0682/full/v4/i2/73.htm
DOI	http://dx.doi.org/10.5662/wjm.v4.i2.73

Full Article (PDF)	WJM-4-73.pdf
Full Article (Word)	WJM-4-73.doc
Manuscript File	7561-Review.doc
Answering Reviewers	7561-Answering Reviewers.pdf
Copyright License Agreement	7561-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7561-Language certificate.pdf
Peer-review Report	7561-Peer review.pdf
Scientific Editor Work List	7561-Scientific editor work list.doc