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Articles Published Processes
7/19/2022 3:37:28 AM | Browse: 408 | Download: 948
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Received |
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2022-02-09 02:37 |
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Peer-Review Started |
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2022-02-09 02:38 |
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To Make the First Decision |
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Return for Revision |
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2022-04-13 01:28 |
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Revised |
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2022-04-27 23:45 |
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Second Decision |
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2022-06-06 03:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-17 22:56 |
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Articles in Press |
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2022-06-17 22:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-06-22 07:42 |
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Publish the Manuscript Online |
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2022-07-19 03:37 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Panagiota Gianni, Mark Goldin, Sam Ngu, Stefanos Zafeiropoulos, Georgios Geropoulos and Dimitrios Giannis |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dimitrios Giannis, MD, MSc, Surgeon, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health Instutute, 500 Hofstra Blvd, Hempstead, NY 11549, United States, New York, New York NY 11549, United States. dimitrisgiannhs@gmail.com |
| Key Words |
COVID-19; Complement; Microvascular injury; Thromboembolism; Cytokine storm; Thrombotic microangiopathy |
| Core Tip |
Current evidence supports the role of excessive complement activation with subsequent illness progression and development of a complement-dependent cytotoxic tissue damage with detrimental effects in coronavirus disease 2019 (COVID-19) patients, including thromboembolic complications. Based on its role in the development of the cytokine storm and thrombogenesis in COVID-19, the complement system is an appealing treatment target with promising results from preliminary reports. Whether inhibition of upstream (C3, C1) or terminal (C5, C5a, or C5aR) components is of equal importance remains to be elucidated, however, preliminary results from several ongoing clinical trials show benefit in terms of 28-d mortality and pulmonary embolism. |
| Publish Date |
2022-07-19 03:37 |
| Citation |
Gianni P, Goldin M, Ngu S, Zafeiropoulos S, Geropoulos G, Giannis D. Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review. World J Exp Med 2022; 12(4): 53-67 |
| URL |
https://www.wjgnet.com/2220-315x/full/v12/i4/53.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v12.i4.53 |
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