BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/19/2022 3:37:28 AM | Browse: 257 | Download: 520
Publication Name World Journal of Experimental Medicine
Manuscript ID 75660
Country/Territory United States
Received
2022-02-09 02:37
Peer-Review Started
2022-02-09 02:38
To Make the First Decision
Return for Revision
2022-04-13 01:28
Revised
2022-04-27 23:45
Second Decision
2022-06-06 03:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-06-17 22:56
Articles in Press
2022-06-17 22:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-06-22 07:42
Publish the Manuscript Online
2022-07-19 03:37
ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Review
Article Title Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review
Manuscript Source Invited Manuscript
All Author List Panagiota Gianni, Mark Goldin, Sam Ngu, Stefanos Zafeiropoulos, Georgios Geropoulos and Dimitrios Giannis
ORCID
Author(s) ORCID Number
Panagiota Gianni http://orcid.org/0000-0001-9246-1234
Mark Goldin http://orcid.org/0000-0002-1147-5541
Sam Ngu http://orcid.org/0000-0002-2256-067X
Stefanos Zafeiropoulos http://orcid.org/0000-0002-3284-2515
Georgios Geropoulos http://orcid.org/0000-0002-2066-7975
Dimitrios Giannis http://orcid.org/0000-0001-9246-976X
Funding Agency and Grant Number
Corresponding Author Dimitrios Giannis, MD, MSc, Surgeon, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health Instutute, 500 Hofstra Blvd, Hempstead, NY 11549, United States, New York, New York NY 11549, United States. dimitrisgiannhs@gmail.com
Key Words COVID-19; Complement; Microvascular injury; Thromboembolism; Cytokine storm; Thrombotic microangiopathy
Core Tip Current evidence supports the role of excessive complement activation with subsequent illness progression and development of a complement-dependent cytotoxic tissue damage with detrimental effects in coronavirus disease 2019 (COVID-19) patients, including thromboembolic complications. Based on its role in the development of the cytokine storm and thrombogenesis in COVID-19, the complement system is an appealing treatment target with promising results from preliminary reports. Whether inhibition of upstream (C3, C1) or terminal (C5, C5a, or C5aR) components is of equal importance remains to be elucidated, however, preliminary results from several ongoing clinical trials show benefit in terms of 28-d mortality and pulmonary embolism.
Publish Date 2022-07-19 03:37
Citation Gianni P, Goldin M, Ngu S, Zafeiropoulos S, Geropoulos G, Giannis D. Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review. World J Exp Med 2022; 12(4): 53-67
URL https://www.wjgnet.com/2220-315x/full/v12/i4/53.htm
DOI https://dx.doi.org/10.5493/wjem.v12.i4.53
Full Article (PDF) WJEM-12-53.pdf
Full Article (Word) WJEM-12-53.docx
Manuscript File 75660_Auto_Edited-LJH-LS.docx
Answering Reviewers 75660-Answering reviewers.pdf
Audio Core Tip 75660-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 75660-Conflict-of-interest statement.pdf
Copyright License Agreement 75660-Copyright license agreement.pdf
Supplementary Material 75660-Supplementary material.pdf
Peer-review Report 75660-Peer-review(s).pdf
Scientific Misconduct Check 75660-Bing-Liu JH-2.jpg
Scientific Misconduct Check 75660-CrossCheck.jpg
Scientific Editor Work List 75660-Scientific editor work list.pdf