| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Minireviews |
| Article Title |
Obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli, Tsukamurella tyrosinosolvens: Minireview of a rare opportunistic pathogen
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Daisuke Usuda, Risa Tanaka, Makoto Suzuki, Shintaro Shimozawa, Hayabusa Takano, Yuta Hotchi, Shungo Tokunaga, Ippei Osugi, Risa Katou, Sakurako Ito, Kentaro Mishima, Akihiko Kondo, Keiko Mizuno, Hiroki Takami, Takayuki Komatsu, Jiro Oba, Tomohisa Nomura and Manabu Sugita |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Daisuke Usuda, MD, MSc, PhD, Doctor, Doctor, Senior Lecturer, Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima-ku 177-8521, Tokyo, Japan. d.usuda.qa@juntendo.ac.jp |
| Key Words |
Tsukamurella tyrosinosolvens; Gram-positive bacilli; Opportunistic infection; Sequence-based identification; Matrix-assisted laser desorption ionization time-of-flight mass spectrometry; Combination antibiotic therapy |
| Core Tip |
Tsukamurella species are obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli that are found in various environments, including soil, water, and sludge. In 2016, there was a reclassification of species within the genus Tsukamurella, merging the species Tsukamurella tyrosinosolvens (T. tyrosinosolvens) and Tsukamurella carboxydivorans. To date, human infections are very rare, and reported infections include pneumonia, brain abscesses, catheter-related bloodstream infections, ocular infections, and bacteremia in patients who are immunocompromised. The golden standards for diagnosis and optimal management still remain to be determined. Immunocompromised patients often experience severe cases due to infection, and life-threatening T. tyrosinosolvens events associated with dissemination and/or failure of source control have occurred. Favorable prognoses can be achieved through earlier identification of the cause of infection, as well as successful management, including appropriate antibiotic therapy together with source control. Further analyses of similar cases are required to establish the most adequate diagnostic methods and treatment regimens for infections. |
| Publish Date |
2022-08-16 01:35 |
| Citation |
Usuda D, Tanaka R, Suzuki M, Shimozawa S, Takano H, Hotchi Y, Tokunaga S, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Oba J, Nomura T, Sugita M. Obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli, Tsukamurella tyrosinosolvens: Minireview of a rare opportunistic pathogen. World J Clin Cases 2022; 10(24): 8443-8449 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i24/8443.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i24.8443 |
