Publication Name	World Journal of Gastroenterology
Manuscript ID	7568
Country	China

Received	2013-11-25 14:55
Peer-Review Started	2013-11-25 15:17
To Make the First Decision	2013-12-16 17:22
Return for Revision	2013-12-17 19:55
Revised	2014-01-10 22:15
Second Decision	2014-02-20 09:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-02-20 09:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-17 14:15
Typeset the Manuscript	2014-04-16 19:06
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Xiang-Fen Ji, Yu-Chen Fan, Shuai Gao, Yang Yang, Jian-Jun Zhang and Kai Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81171579 National Natural Science Foundation of China 81201287 National Natural Science Foundation of China 81371832
Corresponding Author	Kai Wang, MD, PhD, Department of Hepatology, Qilu Hospital of Shandong University and Institute of Hepatology, Shandong University, No. 107, Wenhuaxi Road, Jinan 250012, Shandong Province, China. wangdoc876@126.com
Key Words	MT1M; MT1G; Methylation; Serum biomarker; Hepatocellular carcinoma
Core Tip	DNA methylation of tumor suppressor gene promoter regions appears to be a valuable biomarker in many tumors, including hepatocellular carcinoma (HCC). We found that aberrant serum metallothionein 1M (MT1M) promoter methylation gave higher specificity to discriminate HCC from chronic hepatitis B and normal controls. In contrast, combined methylation of serum MT1M and metallothionein 1G promoters showed higher diagnostic sensitivity. This indicates that they may be used as potential biomarkers for noninvasive detection of HCC.
Publish Date	2014-04-29 09:53
Citation	Ji XF, Fan YC, Gao S, Yang Y, Zhang JJ, Wang K. MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma. World J Gastroenterol 2014; 20(16): 4723-4729
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4723.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4723

Full Article (PDF)	WJG-20-4723.pdf
Full Article (Word)	WJG-20-4723.doc
Manuscript File	7568-Review.doc
Answering Reviewers	7568-Answering reviews.pdf
Copyright License Agreement	7568-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7568-Language certificate.PDF
Peer-review Report	7568-Peer review(s).pdf
Scientific Editor Work List	7568-Scientific editor work list.doc